COLLECTION AND BANKING OF BIOLOGICAL SPECIMENS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者的研究机构。 本研究方案的目的是帮助研究人员更多地了解儿童肥胖症。从这组正在接受减肥手术的独特患者中收集的血液、脂肪、胃肠道组织和肝脏组织可能包含导致儿童极度肥胖的病理生理机制以及大规模减肥有益于这些个体健康的机制的线索。发生这种情况的机制尚不清楚，但可能涉及人类前肠内分泌功能以及能量平衡途径的根本改变。详细了解减肥手术治疗产生如此巨大的形态学和生化变化的机制，可以探索不需要侵入性、风险性手术的替代治疗模式的潜在发展。该协议允许采集关键样本，以创建手术前后患者生物标本的长期储存库。此外，还收集了既往病史、人口统计学、人体测量学、手术和实验室信息，以选择用于肥胖和相关疾病的假设驱动研究的标本。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this research protocol is to help researchers learn more about pediatric obesity. Blood, fat, gastrointestinal tissue and liver tissue collected from this unique group of patients who are undergoing bariatric surgery may harbor clues to the pathophysiologic mechanisms that lead to extreme pediatric obesity and the mechanisms by which massive weight loss benefits the health of these individuals. The mechanism by which this occurs is unclear, but likely involves fundamental alterations in the endocrinologic function of the human foregut as well as energy balance pathways. A detailed understanding of the mechanisms by which bariatric surgical therapy produces such dramatic morphologic and biochemical changes can be explored for the potential development of alternative treatment paradigms that do not require invasive, risky procedures. This protocol allows for the acquisition of key samples to create a long-term repository of biological specimens from patients both before and after surgery. In addition, past medical history, demographic, anthropometric, surgical, and laboratory information is collected to permit selection of specimens to be used in hypothesis-driven research studies of obesity and related disorders.