IMMUNE RESPONSE TO VARICELLA VACCINATION IN SUBJECTS WITH ATOPIC DERMATITIS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 研究接种水痘疫苗作为替代疫苗的免疫反应有望获得有关AD儿童对活病毒疫苗免疫反应变化的重要信息。了解阿尔茨海默病儿童和非阿尔茨海默病儿童免疫反应的差异，可能有助于开发更安全的天花疫苗，或者更好地治疗疫苗并发症。该方案的中心假设是，接种水痘疫苗的AD儿童与非特应性对照组相比，由于免疫系统的Th2极化，其对水痘的CMI将减少。我们推测，他们的免疫系统向Th2反应的两极分化将导致CM1下降。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Investigating the immune response to varicella vaccination as a surrogate is expected to yield important information about alterations in the immune response to live virus vaccines in children with AD. Understanding the differences in the immune response in children with and without AD may allow for the development of safer vaccines for smallpox or, alternatively, better treatments for vaccine complications. The central hypothesis of this protocol is that children with AD who are immunized with varicella vaccine will have a decreased CMI to varicella in comparison to nonatopic controls, because of Th2 polarization of their immune system. We postulate the polarization of their immune system toward a Th2 response will result in decreased CM1.