IMAGING AND MODELING THERAPEUTIC MECHANISMS OF ACTION

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 目的：该提案的长远愿景是发展成像技术，以研究脑疾病治疗干预的作用机制。 该提案的直接目标是研究特发性帕金森病治疗的作用机制。（IPD）。 特别是，我们建议研究李西尔弗曼语音治疗（LSVT）。 行为疗法的作用机制，一般来说，和言语疗法，在很大程度上是未知的。 具体项目将使用帕金森病（PD）作为大脑疾病的模型。 研究人员将使用语言治疗（Lee Silverman Voice Treatment，LSVT）作为治疗方法。 本研究的总体目的是使用功能成像来探讨LSVT治疗PD患者发音减退的作用机制。 方法：PD受试者将被招募、成像、LSVT培训并重新成像。 将使用四种成像技术：PET、功能性MRI、经颅磁刺激和静息状态MRI。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. OBJECTIVE: The long-range vision of this proposal is to develop imaging techniques to study mechanisms of action of therapeutic interventions in brain disorders. The immediate goal of this proposal is to study mechanisms of action of treatment in Idiopathic Parkinson's Disease. (IPD). In particular, we propose to study Lee Silverman Voice Treatment (LSVT). The mechanism of action of behavioral therapies, in general, and of speech therapy, is largely unknown. The specific project will use Parkinson's Disease (PD) as a model of brain disorders. The investigators will use speech therapy (Lee Silverman Voice Treatment, LSVT) as their treatment. The overall aim of this study is to use functional imaging to explore mechanisms of action of LSVT in the treatment of hypophonia in PD. METHODS: Subjects with PD will be recruited, imaged, trained in LSVT, and re-imaged. Four imaging techniques will be used: PET, functional MRI, transcranial magnetic stimulation, and resting state MRI.