VITAMIN D DEFICIENCY: INSULIN RESISTANCE AND FGF-23

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 数据表明，维生素D缺乏(1)导致胰岛素抵抗，(2)影响一种新的磷酸盐调节激素--成纤维细胞生长因子-23的调节。我们将测试维生素D缺乏的治疗是否会改善胰岛素抵抗并增加成纤维细胞生长因子-23。在超过12周的时间里，100名维生素D缺乏的健康受试者将被随机分配到钙500 mg Bid和维生素D 50000 IU QWEEK或安慰剂。如果得到证实，这些数据将(1)论证维生素D缺乏的治疗可以被用作预防糖尿病的策略，以及(2)增加对一种新的重要激素的理解。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Data suggest that vitamin D deficiency (1) contributes to insulin resistance and (2) affects the regulation of a new phosphate-regulating hormone, FGF-23. We will test if treatment of vitamin D deficiency improves insulin resistance and increases FGF-23. Over 12 weeks, 100 healthy vitamin D deficient subjects will be randomly assigned to calcium 500mg BID and either vitamin D 50,000 IU QWEEK or placebo. If confirmed, these data would (1) argue that treatment of vitamin D deficiency could be used as a strategy for the prevention of diabetes mellitus and (2) add to the understanding of a new and important hormone.