EFFECT OF ISOMETRIC HANDGRIP TRAINING ON ARTERIAL BLOOD PRESSURE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究将检验这样一种假设，即8周的等长握力训练将降低老年人的静息和动态血压。研究人员还假设，等长握力训练导致的血压下降将与1)减少静息状态下的交感神经流出；2)将交感神经流出的压力反射控制重新设置为新的较低血压水平；3)改善微循环和导管动脉血管扩张功能；以及4)有利于血管扩张的循环血管收缩和血管扩张物质之间的平衡改变。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study will test the hypothesis that eight weeks of isometric handgrip training will reduce both resting and ambulatory blood pressure in older adults. The investigators also hypothesize that isometric handgrip training-induced decreases in blood pressure will be associated with 1) reduced sympathetic outflow at rest; 2) resetting of baroreflex control of sympathetic outflow to the new lower level of blood pressure; 3) improved microcirculatory and conduit artery vasodilator function; and 4) a shift in the balance between circulating vasoconstrictor and vasodilator substances favoring vasodilation.