Comparison of kidney function measurement methods in the community

描述(由申请人提供)： 项目简介：应聘者是一名肾科医生，于2006年7月1日开始在梅奥诊所工作。在过去四年的实习期间，候选人获得了临床研究硕士学位，第一次撰写了10篇同行评议文章，并获得了机构(T32)和个人(F32)国家研究奖。他在慢性肾脏疾病流行病学和肾功能方法方面的专业知识得到了全国的关注。他是疾病控制和预防中心的赠款审查员，并将主持美国肾脏学会肾脏周(2006)的一个研讨会。 环境将包括梅奥诊所-罗切斯特，在那里他将有一个肾脏病和流行病学的联合任命。他的赞助人、医学博士、医学教授斯蒂芬·特纳将为他提供访问数据的途径，并将他培训为一名独立调查员。他的指导团队还将包括两名流行病学教授、一名生物统计学副教授和肾功能实验室的联席主任，该实验室每年进行5500次肾功能金标准测量。 该项目将比较黄金标准方法(异硫氰酸酯清除法)和临床实践和大多数研究中使用的更方便但可能不太准确的方法(血清肌酐、胱抑素C、估计方程和肌酐清除法)之间的肾功能测量。该项目的独特之处将是在社区样本(导师队列和候选人队列)中比较这些肾功能方法。将确定肾功能测量方法对冠状动脉钙化的影响以及与慢性肾脏疾病相关的危险因素。 相关报道：在美国，有800万成年人的肾功能有中度到严重的下降，面临着昂贵的病态干预(透析或移植)和心血管疾病的风险。需要对肾功能方法进行验证，以便在早期阶段识别慢性肾脏疾病，确定其危险因素，并开发新的治疗策略。

DESCRIPTION (provided by applicant): Project Summary: The candidate is a nephrologist starting a staff position at the Mayo Clinic on July 1st, 2006. During the past 4 years as a nephrology trainee, the candidate obtained a Master's degree in Clinical Research, first-authored 10 peer-reviewed articles, and received institutional (T32) and individual (F32) National Research Awards. His expertise in the epidemiology of chronic kidney disease and in kidney function methods has gained national attention. He was a grant reviewer for the Centers for Disease Control and Prevention and will moderate a symposium at the American Society of Nephrology Renal Week (2006). The environment will consist of Mayo Clinic - Rochester, where he will have a joint appointment in Nephrology and Epidemiology. His sponsor, Stephen Turner, M.D., Professor of Medicine, will provide him with access to data and train him to be an independent investigator. His mentorship team will also include two Professors of Epidemiology, an Associate Professor of Biostatistics, and the Co-director of the Renal Function Laboratory where 5500 'gold-standard' kidney function measurements are performed annually. The project will compare kidney function measurements between a gold standard method (iothalamate clearance) and more convenient, but potentially less accurate methods, used in clinical practice and in most studies (serum creatinine, cystatin C, estimating equations, and creatinine clearance). The unique feature of this project will be to compare these kidney function methods in community-based samples (mentor's cohort and candidate's cohort). The effect of the kidney function measurement method on coronary artery calcification and risk factor associations with chronic kidney disease will be determined. Relevence: In the United States, 8 million adults have moderate-to-severe reductions in kidney function and are at risk for costly morbid interventions (dialysis or transplantation) and cardiovascular disease. Validation of kidney function methods is needed to identify chronic kidney disease at an earlier stage, characterize its risk factors, and develop new treatment strategies.