THE THREE-DIMENSIONAL STRUCTURE OF CALC, A POTENT ANTIBIOTIC BINDING PROTEIN

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项合作旨在确定蛋白质Calc的三维结构，Calc是一种小单体蛋白质[1]。3D结构可以为了解非常特定的抗生素结合和后续反应的细节、克服病原菌耐药性的药物设计以及抗癌药物提供有价值的信息。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This collaboration is aimed at the determination of the three dimensional structure of the protein CalC, a small monomeric protein [1]. The 3D structure could yield valuable information for understanding the details of the very specific antibiotic binding and the subsequent reaction, for the design of drugs to overcome the resistance of pathogenic bacteria as well as for anticancer drugs.