DEVELOPMENT SMALL ANIMAL DIGITAL SUBTRACTION ANGIOGRAPHY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 具体目标1：我们将探索使用几种不同的K发射X射线源(W、Mo、Rh)来提高小动物数字减影血管成像的对比度和噪声。使用K发射器将通过以下方面改善噪声对比度：1)K发射器在低能量下的通量产生比Bremstrhalung高得多；2)探测器荧光粉的量子检测效率在较低能量下高得多(检测荧光粉必须很薄，以限制光散射造成的分辨率下降)；以及3)软组织、钙化和碘/Gd(潜在的血管造影剂)之间的光电吸收差异在较低能量下增加。 具体目标2：在具体目标1描述的模拟结果的基础上，我们将改进我们现有的用于小动物数字减影血管造影术的微型X射线系统。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Specific Aim 1: We will explore the use of several different K emission X-ray sources (W, Mo, Rh) to improve the contrast-to-noise for small animal digital subtraction angiography. Use of a K emitter will improve contrast to noise by: 1) flux production of the K emitters is much more efficient at low energies than Bremstrhalung; 2) the quantum detection efficiency of the detector phosphors is much higher at lower energies (detecting phosphors must be thin to limit resolution degradation from light scatter); and 3) photoelectric absorption differences between soft tissue, calcification and iodine/gadolinium (potential vascular contrast agents) increase at lower energy. Specific Aim 2: Based on simulation results described in Specific Aim 1, we will enhance our current micro-X-ray system for small animal digital subtraction angiography.