FLIP ANGLE CALIBRATION FOR HIGH RESOLUTION MAPPING

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 近年来，超极化氦-3磁共振成像(HP-3He-MRI)被认为是定量评估肺参数的理想成像工具。这项技术可以在微观和宏观水平上提供肺结构信息。在这项工作中，我们提出了一种获得肺部远程扩散系数的高分辨率映射的方法。我们在模型和动物模型中验证了该方法的有效性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In recent years hyperpolarized helium-3 magnetic resonance imaging (HP 3He MRI) shows promise as an ideal imaging tool for quantitative assessments of pulmonary parameters. This technique can provide lung structure information at both microscopic and macroscopic levels. In this work, we present a method for obtaining a high resolution mapping of the long range diffusion coefficient in the lung. We demonstrate the validity of this method in phantom and animal models.