PROSTATE TUMOR PROGRESSION ALTERED BY PHYTO ESTROGENS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 植物雌激素的摄入被认为与前列腺癌的发生有很大关系。本研究采用小鼠前列腺癌（TRAMP）模型，研究植物雌激素对前列腺癌的化学预防作用。我们假设植物雌激素在体内通过雌激素受体（ER）介导的途径起作用。我们能够利用ER缺陷小鼠来解决这种ER依赖性在该研究中测量的终点是：前列腺肿瘤进展;雄激素受体、ER-α和ER-β的表达;前列腺肿瘤相关基因的甲基化及其信号通路的研究植物雌激素的化学预防作用机制的研究有助于前列腺肿瘤的预防和治疗人类前列腺素

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cosumption of phytoestrogens are suspected to have great impacts on prostate cancer risk.Using a TRansgenic Adenocarcinoma of Mouse Prostate (TRAMP)model, we aim to study the chemopreventive effects of dietary phytoestrogens on prostate cancer progression.We hypothesis that phytoestrogens act through an estrogen receptor (ER)mediated pathway in vivo.We are able to address this ER dependency using the ER deficient mice (ER-alpha KO,ER-beta KO,ER-alpha & beta KO)expressing the TRAMP transgene.The endpoints being measured in this study are:prostate tumor progression;expression of androgen receptor,ER - alpha and ER-beta;differetial methylation of prostate tumor related genes and involvemen of signaling pathways.Understanding mechanisms of chemopreventive effects of phytoestrogens will contribute to prevention and therapeutics of human prosate