1 FORCE-INDUCED ACTIVATION OF TALIN 2 MECHANICS AND SELF-ASSEMBLY OF THE SYNT

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 我们参与了两个需要对蛋白质进行分子动力学模拟的项目。首先，我们正在研究Talin机械转导的潜在机制，talin是一种在细胞锚定细胞外基质的位置发现的蛋白质。Talin可以通过在外力作用下展开以暴露蛋白纽蛋白的结合位置来开始信号级联。第二，我们正在研究多肽[RARADA]2的机械和自组装特性，这是一种细胞支架材料。我们使用原子模拟来测量散体材料行为的过程粒度模型的参数。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We are engaged in two projects requiring molecular dynamic simulations of proteins. First, we are examining a potential mechanism of mechanotransduction by talin, a protein found at sites where a cell anchors to the extracellular matrix. Talin could begin a signaling cascade by unfolding under an applied force to expose a binding site for the protein vinculin. Second, we are investigating the mechanical and self-assembly properties of the peptide [RARADADA]2, a cell scaffold material. We use atomistic simulations to measure parameters for course-grained models of bulk material behavior.