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ORIGINS OF STEREO-SELECTIVE CATALYSIS BY ANTIBODIES

ORIGINS OF STEREO-SELECTIVE CATALYSIS BY ANTIBODIES
抗体立体选择性催化的起源
批准号：
7601673
负责人：
KENDALL N HOUK
金额：
$0.18万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
项目状态：
已结题
起止时间：
2007-05-01 至 2008-04-30
来源：
https://reporter.nih.gov/project-details/7601673
关键词：
AntibodiesAntibody Binding SitesCatalysisComputer Retrieval of Information on Scientific Projects DatabaseDockingFundingGoalsGrantInstitutionReactionResearchResearch PersonnelResearch Project GrantsResourcesSourceStructureUnited States National Institutes of Healthcatalystinsightquantum

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中文摘要
翻译
这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 使用Autodock和Autodock Toolkit（ADT）研究抗体催化。这涉及量子力学计算的过渡结构对接到抗体结合位点，以获得立体选择性催化的见解。 该研究项目的目标是了解抗体催化剂加速反应和诱导立体选择性的机制。
英文摘要
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Using Autodock and Autodock Toolkit (ADT) to study antibody catalysis. This involves quantum mechanically computed transition structures docked into antibody binding sites to obtain insights into stereoselective catalysis. The goal of this research project is to understand the mechanism by which antibody catalysts accelerate the reaction and induce stereoselectivity.
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Steroselectivity of Synthetically Valuable Enzyme Catalysts
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