MASS SPECTROMETRIC ANALYSIS OF HISTONE MODIFICATIONS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 蛋白质的翻译后修饰通常调节它们的活性。我们正在探索组蛋白的修饰，组蛋白是染色体的中心构件。特别是，在这个项目中，我们试图确定形成组蛋白H3蛋白修饰的酶，组蛋白H3蛋白是在DNA复制过程中形成的，对基因组稳定性至关重要。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Post translational modifications of proteins commonly regulate their activity. We are exploring the modifications of the histone proteins, which are the central building blocks of chromosomes. In particular, in this project we seek to identify the enzyme that forms a modification on the histone H3 protein that is formed during DNA replication and is essential for genome stability.