Migraine Prophylaxis with Precision Spectral Filters

描述（由申请人提供）：偏头痛是一种常见的神经血管疾病，影响约2800万美国人，其中女性占很大比例。偏头痛可持续数小时至数天，并导致隐性残疾和数天的工作损失。除了使人衰弱的疼痛外，偏头痛还经常伴有各种视觉障碍。我们最近的研究支持这样一个假设，即偏头痛患者在视觉先兆下对知觉错觉的高度敏感性与视觉皮层对“强”刺激的过度激活有关。这种超视皮层活动在本申请中被称为视觉皮层应激。视觉皮层压力虽然是由我们研究中的实验刺激产生的，但也可能是由阅读、在电脑上工作、看电视和每天看到某些模式等活动引起的。我们的一般假设是，视觉皮质应激是由于对“强”生理感觉刺激（特别是但不限于视觉）的反应产生了太大的神经（超神经）活动。强烈的生理视觉输入可能导致兴奋通过过度兴奋的皮层扩散，导致神经元不适当地放电，从而导致感知错觉和扭曲，并可能促进偏头痛发作。我们假设，皮质过度兴奋是不均匀的，并且精密的光谱滤波器重新分配皮质兴奋，发生在响应于强烈的视觉刺激。舒适的颜色重新分配的兴奋在这样一种方式，以减少兴奋过度的地区。在本申请中，我们将研究1）通过精密光谱滤波器在相同偏头痛个体中减少异常神经活动和2）减少偏头痛。这些研究将收集试点数据，用于调查皮质激活是否可以预测精密光谱滤波器在降低偏头痛发作频率方面的益处，并将有可能开发一种程序，用于识别最有可能从精密光谱滤波器中受益的人。偏头痛是一种常见的神经血管疾病，影响约2800万美国人，其中女性占很大比例。许多研究表明，有视觉先兆的偏头痛患者（MwA）与视觉皮层的过度激活有关，过度的视觉皮层应激可能导致偏头痛发作。我们最近的研究表明，精密光谱滤波器（PSF）对减少MwA偏头痛发作的有效性为50%，拟议的研究将调查皮层激活是否可以预测PSF在减少偏头痛发作频率方面的益处，因此有可能开发一种程序来识别最有可能从PSF中受益的人。

DESCRIPTION (provided by applicant): Migraine is a common neurovascular disorder, affecting approximately 28 million Americans with a high preponderance in women. Migraine headache pain can last hours to days, and causes covert disability and days lose from work. In addition to debilitating pain, migraine is frequently accompanied by various visual disturbances. Our recent study supports the hypothesis that high susceptibility to perceptual illusions in migraineurs with visual aura is associated with hyper activation in visual cortex in response to "strong" stimuli. This hypervisual cortical activity is called visual cortical stress in this application. The visual cortex stress, although produced by an experimental stimulus in our study, can also result from such activities as reading, working on a computer, watching television, and seeing certain patterns in the day to day. Our general hypothesis is that visual cortical stress results from too great neural (hyperneural) activity in response to "strong" physiological sensory stimulation, particularly but not exclusively visual. A strong physiological visual input may cause a spread of excitation through hyperexcitable cortex, leading to neurons firing inappropriately and thereby resulting in perceptual illusions and distortions and possibly promoting a migraine attack. We hypothesize that the cortical hyperexcitability is non-uniform, and that the precision spectral filters redistribute the cortical excitation that occurs in response to a strong visual stimulus. Comfortable colors redistribute the excitation in such a way as to reduce the excitation in hyperexcitable regions. In this application, we will investigate 1) reduction in abnormal neural activity and 2) reduction in migraine headaches by precision spectral filters in the same migraine individuals. The studies will collect pilot data for investigation of whether cortical activation could predict the benefit of precision spectral filters in reducing the frequency of migraine attacks, and will make it possible to develop a procedure for identifying those most likely to benefit from precision spectral filters. Migraine is a common neurovascular disorder, affecting approximately 28 million Americans with a high preponderance in women. Numerous studies have suggested that migraineurs with visual aura (MwA) are associated with hyper activation in visual cortex and excess visual cortical stress could result in migraine attacks. Our recent study showed a 50% rate of effectiveness of precision spectral filters (PSF) on reduction of migraine attack in MwA, and the proposed studies will investigate whether cortical activation could predict the benefit of PSF in reducing the frequency of migraine attack and therefore make it possible to develop a procedure for identifying those most likely to benefit from PSF.