CORE GRANT FOR VISION RESEARCH

描述(由申请人提供)：我们请求继续支持1977年在西奈山医学院实施的视力研究核心中心助学金。核心中心为视觉研究人员提供共享资源，这些资源对于当前研究计划的继续和新计划的有效开发至关重要。我们的中心由6个被广泛利用的资源和服务模块组成。要求为当地资源难以支持的三个关键单元继续提供NEI资金：机器车间、电子/计算机和组织学/组织处理。其他三个模块：组织培养、共享设备和细胞成像得到了部门和机构的支持，这是他们对我们的视觉研究科学家的承诺的基础。除了通过提供共同的集中服务来提高研究环境和生产率外，P30奖还鼓励和促进合作研究，并努力吸引其他健康相关学科的科学家进行视觉研究。我们的小组由11名拥有NEI补助金的独立调查人员、4名助理调查人员和研究员组成 从事生物化学、药理学、生理学、细胞生物学和神经学等多个学科的研究。活跃的研究领域包括：青光眼；白内障；角膜疾病；角膜修复和免疫学；房水动力学；角膜、晶状体和睫状体上皮细胞的液体和电解质转运；膜受体在调节眼压中的作用；眼动系统的视觉控制；青光眼中谷氨酸兴奋毒性的机制和神经保护方法；光学成像、电生理记录和计算机模拟，以研究视觉系统的结构和动态；以及视网膜退行性疾病。NEI资助的研究人员小组包括7名长期支持NEI的高级教员，4名在前一批资助期间获得NEI R01资助的PIS，以及3名有前途的年轻研究人员，他们正在与未决的NEI R01提案建立竞争力。

DESCRIPTION (provided by applicant): We request continuing support for a Vision Research Core Center Grant at the Mount Sinai School of Medicine that was implemented in 1977. The Core Center provides vision researchers with shared resources that are vital for the continuation of current research programs and efficient development of new programs. Our Center is structured around 6 extensively utilized resource and service modules. Continued NEI funding is requested for three critical modules which are difficult to support with local resources: Machine Shop; Electronics/Computers and Histology/Tissue Processing. The other three modules: Tissue Culture; Shared Equipment and Cellular Imaging are supported by the department and the institution, underlying their commitment to our vision research scientists. In addition to enhancing the research environment and productivity by providing common centralized services, the P30 award stimulates and facilitates collaborative studies and strives to attract to vision research, scientists in other health-related disciplines. Our group consists of 11 independent investigators who have NEI grants, 4 associate investigators and fellows conducting research in several scientific disciplines such as biochemistry, pharmacology, physiology, cell biology, and neurology. Areas of active research include glaucoma; cataracts; corneal diseases; comeal repair and immunology; aqueous humor dynamics; fluid and electrolyte transport in cornea, lens and ciliary epithelium; role of membrane receptors in regulation of intraocular pressure; visual control of the oculomotor system; mechanisms of glutamate excitotoxicity in glaucoma and methods of neuroprotection; optical imaging, electrophysiological recordings and computer simulations to study the architecture and dynamics of the visual system; and degenerative diseases of the retina. The group of NEI-funded investigators includes 7 senior faculty with long-standing NEI support, 4 Pis who received NEI R01 funding during the prior grant period, and 3 promising younger investigators who are establishing their competitiveness with pending NEI R01 proposals.