Facility Core A--Integrative Health Sciences

俄亥俄州立大学环境健康科学核心中心具有悠久的历史，开创了 基础环境健康科学研究已转化为临床研究，影响深远 对公共健康的影响。在最近的资助周期中，转化型人类临床研究 由中心成员发起的包括多种癌症化学预防方法，基于鲑鱼和 啮齿动物模型(Bailey、Dashwood、Ho、Williams)。其他由中心发起的研究已经评估了这种影响 微量营养素对α-硫辛酸-乙酰肉碱和维生素C血压参数的影响(Hagen， Frei)，研究了吸烟者和超级马拉松运动员(Traber，Frei)的维生素E代谢，并调查了 保护和伤害的生物标志物(史蒂文斯、贝克曼、弗雷、特雷伯)。人们对此兴趣浓厚。 中心研究人员发起进一步的小规模人类临床研究项目，通常涉及 3-20名参与者将EHSC的基础科学成果转化为临床相关知识 研究。中心成员目前有10项资助的人类临床研究等待实施， 其中两个已提交资金申请，七个处于规划阶段。新的综合健康科学 已经实施了设施核心(IHSFC)，以满足这一不断增长的需求并培养更多 翻译研究

The Environmental Health Sciences Core Center at OSU has a long history of pioneering integrative research in basic environmental health science that has translated to clinical research with far-reaching public health implications. During the most recent funding cycle, translational human clinical studies initiated by Center members include multiple approaches to cancer chemoprevention based on trout and rodent models (Bailey, Dashwood, Ho, Williams). Other Center-initiated studies have assessed the effect of micronutrients on blood pressure parameters with a-lipoic acid-acetylcarnitine and Vitamin C (Hagen, Frei), studied vitamin E metabolism in smokers and ultramarathoners (Traber, Frei), and investigated biomarkers of protection and injury (Stevens, Beckman, Frei, Traber). There is strong interest among Center investigators in launching further small-scale human clinical research projects typically involving 3-20 participants to translate the basic science accomplishments of the EHSC into clinically relevant research. Center members currently have ten funded human clinical studies awaiting implementation, two submitted for funding, and seven in the planning stages. The new Integrative Health Sciences Facility Core (IHSFC) has been implemented to meet this growing need and foster additional translational researc