EFFECTS OF CIGARETTE SMOKE ON CYCLOXYGENASE-2 IN ORAL MUCOSA

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 基本假设： 这项研究的主要假设是，健康的重度吸烟者会在口腔粘膜中表达更高水平的环氧合酶-2(COX-2)及其相关分子。 具体目标： 1.探讨30例重度吸烟者和30例不吸烟者正常颊(颊)黏膜中COX-2水平的差异。 2.探讨30例不吸烟者口腔正常口腔黏膜COX-2水平与吸烟年限的关系。 3.探讨40例重度吸烟者和40例不吸烟者正常颊(颊)黏膜中表皮生长因子受体(EGFR)酪氨酸激酶及相关分子活化水平的差异。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Primary Hypothesis: The primary hypothesis of this study is that healthy heavy smokers will express higher levels of cyclooxygenase-2 (COX-2) and related molecules in their oral mucosa. Specific Aims: 1. To evaluate the difference in levels of COX-2 in normal appearing buccal (cheek) mucosa (surface lining of the cheek) between 30 heavy smokers and 30 never smokers. 2. To evaluate the association of pack years of cigarette exposure with levels of COX-2 in normal appearing buccal mucosa of 30 never smokers. 3. To evaluate the difference in levels of activation of epidermal growth factor receptor (EGFR) tyrosine kinase and other related molecules in normal appearing buccal (cheek) mucosa (surface lining of the cheek) between 40 heavy smokers and 40 never smokers.