Adolescent Alcohol Abuse: A Twin-Study Perspective

描述：为响应RFA AA-99-003提交的本申请 要求提供五年的支持，以研究 成年和青少年双胞胎中的青少年酒精滥用。这项研究 该提案建立在芬兰正在进行的两项双胞胎家庭研究的基础上。一 这项名为FinnTwin16的研究已经确定了2800对出生于1975-79年的双胞胎，以及 在1991-1995年间，通过问卷调查对他们及其父母进行了评估 双胞胎年满16岁；对双胞胎的后续问卷评估是 在17岁和18岁半的时候做出的。我们建议对 所有这些年龄在22-25岁的芬兰双胞胎，评估他们成年后使用/虐待 酒精及其社会、教育、职业和人际关系 能力。从青少年问卷评估来看，我们有 确定了200对异卵双胞胎以进行密集跟踪；目标同卵双胞胎 被选为极端和谐或极端不和谐的 青少年酗酒。年龄在22-25岁之间，我们将通过 酒精中毒遗传学半结构化评估(SSAGA)，获取它们 进行神经心理测试，并评估他们的电生理 使用企业资源规划范例进行运作。这些同卵双胞胎的家庭内部比较 不和谐的青少年酗酒将有力地考验其 后果。来赞扬这种对早期成人后果的评估 青少年酗酒问题，我们建议对两个出生队列进行深入研究 根据第二项正在进行的研究，出生于1986-87年的485对双胞胎是 被选为该项目的密集研究对象，其中50%在高年级家庭 有酗酒的风险。在2000-01学年14岁的时候，这对双胞胎将是 与青少年SSAGA进行了面谈(使用其他资金)，并作为 这项建议，我们将在采访中附上丰富的神经心理学知识 测试电池并测定唾液中的睾酮和皮质醇。联合起来，这些 靶向的神经生理学、神经心理学和神经内分泌研究 芬兰双胞胎，他们的风险相关数据早些时候已经收集到了， 提供了精辟的神经生物学机制和后果的分析 青春期酗酒。

DESCRIPTION: Submitted in response to RFA AA-99-003, this application requests five years’ support to study consequences and mechanisms of adolescent alcohol abuse in adult and adolescent twin pairs. The research proposal builds on two ongoing twin-family studies conducted in Finland. One study, FinnTwin16, has ascertained 2,800 twin pairs, born 1975-79, and assessed them, and their parents, with questionnaires, in 1991-1995, as the twins reached age 16; follow-up questionnaire assessments of the twins were made at ages 17 and 18 1/2. We propose a fourth questionnaire assessment of all these Finnish twins, at ages 22-25, to evaluate their adult use/abuse of alcohol and their social, educational, occupational and interpersonal competencies. From the adolescent questionnaire assessments, we have identified >200 dizygotic twin pairs for intensive follow-up; the targeted cotwins were selected for extreme concordance or extreme discordance for adolescent alcohol abuse. At ages 22-25, we will interview them with the Semi-Structured Assessment for Genetics of Alcoholism (SSAGA), access them with a neuropsychological test battery and evaluate their electrophysiological function with ERP paradigms. These within-family comparisons of co-twins discordant for adolescent alcohol abuse will robustly test for its consequences. To compliment this appraisal of early adult consequences of adolescent problem drinking, we propose intensive study of two birth cohorts from a second on-going study, FinnTwin12; 485 twin pairs, born 1986-87, are selected for intensive study in that project with 50% at elevated familial risk for alcoholism. At age 14, in years 2000-01, these twin pairs will be interviewed with the adolescent SSAGA (with other funding), and as part of this proposal, we will append to the interview an enriched neuropsychological test battery and assay testosterone and cortisol from saliva. Jointly, these neurophysiological, neuropsychological, and neuroendocrine studies of targeted Finnish twins, for whom risk-relevant data have been collected earlier, will offer incisive analyses of neurobiological mechanisms and consequences of alcohol abuse in adolescence.