CLINICAL TRIAL: HORMONE GEL APPLIED TO WOMEN WITH PITUITARY GLAND PROBLEMS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者的研究机构。 患有脑下垂体功能障碍的女性通常会减少一些激素的产生，包括甲状腺激素，皮质醇和性激素，如雌激素和睾丸激素。 作为治疗的一部分，这些缺乏的激素通常会被替换，但女性中的睾酮除外。 然而，睾丸激素可能在女性中发挥重要作用，特别是在保持瘦体重和增强性欲和整体健康方面。 这项研究，在一般情况下，寻找确定与正常妇女相比，垂体功能障碍的妇女低睾酮的影响。 在查尔斯河德鲁大学，受试者将接受基线血液测试的激素水平，身体成分和肌肉功能的测试，以及问卷测试评估疲劳，认知，主观性功能和生活质量。 在加州大学洛杉矶分校医学中心，将评估性功能的客观指标。 在Charles R。德鲁大学，吸收的睾酮凝胶制剂给予七天将通过一系列的抽血测量，以确定睾酮血清浓度。 这将有助于确定未来研究中睾酮凝胶的适当替代剂量。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Women who have pituitary gland dysfunction often have decreased production of a number of hormones, including thyroid hormonee, cortisol and sex hormones like estrogen and testosterone. As part of the treatment, these deficient hormones are normally replaced with exception of testosterone in women. However, testosterone may play an important role in women especially in terms of maintaining lean body mass and enhancing libido and general well being. This study, in general, looks to identify the effects of low testosterone in women with pituitary dysfunction as compared with normal women. At Charles R. Drew University, the subjects will undergo baseline blood tests for homone levels, tests for body composition and muscle function, as well as questionnaire tests evaluating fatigue, cognition, subjective sexual function and quality of life. At UCLA Medical Center, objective measures of sexual function will be assessed. Also at Charles R. Drew University, the absorption of a testosterone gel preparation given for seven days will be measured through a series of blood draws to determine testosterone serum concentrations. This will enable determination of appropriate replacement dosage of testosterone gel for a future study.