USD MED: NEURAL MECHANISMS OF ADAPTIVE BEHAVIOR

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 南达科他州大学的适应行为神经机制研究中心旨在了解神经系统如何使行为适应环境的变化。 我们中心的主要目的是研究神经通路的结构重组，导致对新的感觉运动体验的适应性行为反应。 神经回路的功能性重组对于在学习和记忆、发育期间和在中枢神经系统对压力的响应中以及在疾病状态期间（诸如在CNS损伤之后和在精神疾病中发生）发生的过程是基本的。 我们的COBRE有五个主要的研究项目，解决感觉运动适应的问题。其中包括研究海马体可塑性机制的蒂莫西·克拉克博士。 Pat Manzerra博士在大鼠模型中研究精神分裂症的谷氨酸受体机制。布莱恩·伯勒尔博士，研究无脊椎动物联想学习的细胞机制。 Pat罗南博士研究RNAi在压力调节中的作用。 福斯特博士和瓦特博士研究压力的神经化学效应及其与成瘾和焦虑症的关系。总之，这些项目的主要目标是有助于理解适应性行为的细胞机制，并发展一个全面的理论，解释适应性运动反应过程中细胞水平上发生的变化。 该中心允许USD研究人员获得新设备，如激光扫描共聚焦显微镜，以加强教师的发展，最重要的是，通过增加新的教师来建立神经科学的基础设施。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Center on NEURAL MECHANISMS OF ADAPTIVE BEHAVIOR at the University of South Dakota is organized to understand how the nervous system adapts behavior to changes in the environment. The main aim of our Center is to study the structural reorganization of neural pathways that results in adaptive behavioral responses to novel sensory-motor experiences. Functional reorganization of neural circuits is fundamental to processes that occur during learning and memory, development, and in the central nervous system's response to stress, and during disease states such as occurs following injury to the CNS and in mental illness. Our COBRE has five primary research projects that address the problem of sensorimotor adaptation. These include Dr. Timothy Clark who studies mechanisms of plasticity in the hippocampus. Dr. Pat Manzerra who studies glutamate receptor mechanisms underlying schizophrenia in a rat model. Dr. Brian Burrell who studies cellular mechanisms of associative learning in invertebrates. Dr. Pat Ronan who examines the role of RNAi in stress regulation. Drs. Forster and Watt who study the neurochemical effects of stress and their relation to addiction and anxiety disorders. Together, the main goal of these projects is to contribute to an understanding of the cellular mechanisms that underlie adaptive behavior and to develop a comprehensive theory that accounts for changes occurring at the cellular level during adaptive motor responses. The Center allows USD researchers to acquire new equipment such as a laser scanning confocal microscope, to enhance faculty development, and most importantly, to build infrastructure in neuroscience by the addition of new faculty members.