Modulation of virus-cellular receptor interactions in picornaviral pathogenesis

人类的胃肠道病毒感染导致各种各样的疾病，从普通感冒到婴儿麻痹和病毒性心肌炎。尽管这些病毒靶向的组织和器官范围很广，但感染启动的方式非常相似。感染的主要步骤是病毒与细胞表面的特定蛋白质结合，类似于锁和钥匙的类比。本项目旨在研究代表性小核糖核酸病毒与其细胞粘附蛋白之间相互作用的性质，以期设计合理的抗病毒策略来阻断病毒细胞粘附和细胞进入。利用在调查为什么某些病毒只感染某些细胞时提出的数据，我们计划根据它们对不同病毒的敏感性来靶向人类肿瘤细胞。

Gastrointestinal viral infections of humans result in a wide variety of illnesses ranging from the common cold to infantile paralysis and viral myocarditis. Despite the wide range of tissues and organs targeted by these viruses, the manner in which infection is initiated is remarkably similar. The primary step in infection is the binding of a virus to a specific protein on the cell surface, similar to the lock and key analogy. This project seeks to investigate the nature of interactions between representative picornaviruses and their cellular attachment proteins with a view to designing rational anti-viral strategies to block virus cell attachment and cell entry. Using the data raised when investigating why some viruses only infect certain cells, we plan to target human tumors cells based on their susceptibilty to different viruses.