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中文摘要
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这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者(PI)可能从另一个NIH来源获得了主要资金, 因此可以在其他CRISP条目中表示。所列机构为 研究中心,而研究中心不一定是研究者所在的机构。 研究服务司通过提供高质量的技术援助、专门的科学程序和获取信息的途径,促进灵长类动物研究项目。按服务收费的费率可收回成本。这些核心配备了训练有素的人员和设备;他们向担任研究服务主管的副主任报告。 辅助生殖技术使用人工授精技术,如ICSI和核移植,扩大了专门的恒河猴模型的生产。该实验室已经产生了恒河猴干细胞,这一事件作为一个开创性的突破而受到国际赞誉。 Endocrine Services提供各种激素和其他物质的检测。 流式细胞仪提供流式分析和细胞分选服务和咨询。 成像和形态学将医学插图,摄影和光学显微镜服务与共聚焦显微镜,图像分析设备和体视学结合在一起。 分子和细胞生物学提供以下服务:猴和其他cDNA的生成,自动测序,大规模质粒和噬菌体制备,试剂供应,实时PCR,培养基制备,细胞系的储存和扩增, 包被的培养皿和盖玻片,以及细胞系的转染和克隆。 病毒学提供设施,专业知识,试剂,标准化检测,动物协议管理和培训,在使用传染性病原体的研究计划。 除了这些核心之外,该中心还为其他核心提供支持,这些核心为中心科学家提供重要的研究服务,包括斑点微阵列。 此外,还有三个特殊的资源计划:灵长类动物衰老研究进展(PAS);遗传资源和信息学计划(GRIP);和高级成像研究中心(AIRC)。 上述附属科学家是接受核心服务的外部研究者。
英文摘要
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Research Services Division facilitates primate research projects by providing quality technical assistance, specialized scientific procedures and access to information. Fee-for-service rates provide cost recovery. The cores are staffed with trained personnel and equipment; they report to the Associate Director, serving as Head of Research Services. Assisted Reproductive Technology expands the production of specialized rhesus models using artificial insemination techniques such as ICSI and nuclear transfer. The lab has produced rhesus monkey stem cells, an event that received international praise as a seminal breakthrough. Endocrine Services provides assays for a wide variety of hormones and other substances. Flow Cytometry provides flow analysis and cell sorting services and consultation. Imaging and Morphology consolidates medical illustrations, photography and light microscopy services together with the confocal microscopy, image analysis facility and stereology. Molecular and Cellular Biology provides the following services: generation of monkey and other cDNAs, automated sequencing, large scale plasmid and phage preparation, reagent supply, real-time PCR, media preparation, storage and amplification of cell lines, coated cultureware and slip covers, and transfection and cloning of cell lines. Virology provides facilities, expertise, reagents, standardized assays, animal protocol management and training in the use of infectious agents for research programs. In addition to these cores, the Center also provides support for other cores that provide important research services for Center scientists, including Spotted Microarray. In addition there are three special resource programs: Progress for the Primate Aging Study (PAS); the Genetics Resource and Informatics Program (GRIP); and the Advanced Imaging Research Center (AIRC). Affiliated scientists listed above are external investigators who are receipients of core services.
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Mouse Model for Diseases of Protein Misfolding
High Throughput Screening for Pharmacoperones of the V2 Receptor
High Throughput Screening for Pharmacoperones of the V2 Receptor
High Throughput Screening for Pharmacoperones of the V2 Receptor
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