Modulation of TGF-beta signaling by CDA1 in the diabetic vasculature

细胞分裂自身抗原1(CDA1)是我们几年前发现的一种分子。最近，我们发现CDA1通过劫持和控制现有的转化生长因子-β信号通路，在导致血管瘢痕和僵硬中发挥着独特的作用。我们将探索利用CDA1的这一独特特性来治疗血管硬化和相关疾病的可能性，如动脉粥样硬化和心脏病发作，特别是在糖尿病的情况下。

Cell Division Autoantigen 1 (CDA1) is a molecule we identified several years ago. Recently we found that CDA1 played an unique role in causing blood vessels to scar and become stiff by hijacking and controlling the existing transforming growth factor-beta (TGF-beta) signaling pathway. We will explore the possibility to use this unique property of CDA1 to treat the blood vessel hardening and related diseases such as atherosclerosis and heart attacks, particularly in the setting of diabetes.