Integrated Wireless Tracking and Dosimetry for Radiation Oncology

描述（由申请人提供）：该提案寻求NIH/NIBIB探索/发展研究资助计划下的R21资助，以开发用于无线肿瘤跟踪和原位辐射剂量测定的新型集成微应答器。这种微型设备将是一个非常宝贵的工具，在放射肿瘤学的实时接收剂量测量和肿瘤运动管理。申报器械的主要预期应用是（1）胸部和腹部肿瘤的立体定向体部放射治疗（SBRT）和（2）前列腺癌的高剂量放射（HDR）治疗。对于SBRT应用，将在肿瘤组织及其附近植入应答器，以有效监测治疗时的剂量输送和组织跟踪。对于HDR前列腺癌治疗，该装置的熟练应用将需要将其放置在穿过尿道的导管中，以在植入期间监测沿着放射敏感膜管的剂量，或者放置在附接到放置在直肠内的球囊的导管中（球囊用于更好地固定靶和更有利地在直肠壁中分布剂量）。对于辐射剂量测量，我们将探索一种器件结构和检测方案的基础上的耗尽电容的变化与辐射产生的负电荷在氧化铪栅极的金属绝缘体（MOS）结构。为了实时监测肿瘤位置，我们将使用具有上级信噪比性能和增强询问范围的磁跟踪方法。这两种器件都将集成在同一个硅衬底上，并从电感耦合链路（不需要电池）接收功率，从而简化了封装和封装。放射肿瘤学的集成无线跟踪和剂量测定这是一个修订后的R21申请，旨在响应NIH/NIBIB探索/发展研究资助计划，开发一种用于无线肿瘤跟踪和原位辐射剂量测定的新型集成微应答器。虽然评价是积极的（得分225），但专家组提出了几个问题，我们已在本次重新提交的材料中解决了这些问题。我们根据评论添加或更改的段落使用不同的字体（Palatino Linotype）。

DESCRIPTION (provided by applicant): This proposal seeks funding for an R21 grant under the NIH/NIBIB Exploratory/Developmental Research Grant Program to develop a novel integrated micro-transponder for wireless tumor tracking and in-situ radiation dosimetry. This microdevice will be an invaluable tool in radiation oncology for real-time received dosage measurements and tumor motion management. The primary envisioned application of the proposed device is for (1) Stereotactic Body Radiation Therapy (SBRT) treatments of thoracic and abdominal tumors and for (2) High Dose Radiation (HDR) treatment of prostate cancer. For SBRT applications transponders will be implanted in the tumor tissue and its vicinity for effective monitoring of dose delivery and tissue tracking at treatment. For HDR prostate cancer treatment the proficient application of the device would require its placement in the catheter passing through urethra to monitor dose along the radiosensitive membranous tube during implant or in the catheter attached to the balloon placed inside the rectum (balloon being utilized for better immobilization of the target and more favorable dose distribution in the rectum wall). For the radiation dose measurement, we will explore a device structure and detection scheme based on the depletion capacitance change associated with radiation-generated negative charge in the hafnium oxide gate of a metal-on-insulator (MOS) structure. In order to monitor tumor location in real-time, we will use a magnetic tracking method with superior signal- to-noise performance and enhanced interrogation range. Both of these devices will be integrated on the same silicon substrate and receive power from an inductively coupled link (no battery required), hence simplifying the packaging and encapsulation. Integrated Wireless Tracking and Dosimetry for Radiation Oncology This is a revised R21 application submitted in response to the NIH/NIBIB Exploratory/Developmental Research Grant Program to develop a novel integrated micro-transponder for wireless tumor tracking and in-situ radiation dosimetry. Although the reviews were positive (score 225), several concerns were raised by the panel which we have addressed in the present re-submission. The paragraphs that we have added or changed in response to the review use a different font (Palatino Linotype).