Molecular basis for stress-induced gene regulation—a model system to understand transcriptional deregulation in cancer and neurological disease

基因转录失调在癌症形成中起着关键作用。因此，了解基因转录的分子基础以及肿瘤细胞如何劫持这一过程非常重要。本项目主要研究胁迫诱导基因表达的分子基础。这对于理解癌症的分子基础特别重要，因为应激诱导基因被乳腺癌、结肠癌、肺癌和前列腺癌中涉及的转录因子激活。

Deregulated gene transcription plays a critical role in cancer formation. It is therefore important to understand the molecular basis of gene transcription and how tumour cells hijack the process. In this Project, we will study the molecular basis of stress-inducible gene expression. This is particularly important for understanding the molecular basis of cancer as stress-inducible genes are activated by transcription factors implicated in breast, colon, lung, and prostate cancers.