Growth Control
Growth Control
批准号:
7714188
负责人:
MICHELE PAGANO
金额:
$1.45万
依托单位国家:
美国
项目类别:
财政年份:
2008
资助国家:
美国
项目状态:
已结题
起止时间:
2008-04-18 至 2013-02-28
关键词:
Animal ModelAreaClinicalCommitDevelopmentEnrollmentExertionFacultyFosteringFundingGenesGenetic TranscriptionGoalsGrantGrowthHumanInstitutesInvestigator-Initiated ResearchKnowledgeMalignant - descriptorMalignant NeoplasmsMolecularMutationNeoplasmsPathway interactionsPatternPeer Review OrganizationsPhasePublicationsRecommendationRecruitment ActivityResearchResearch PersonnelResource SharingSamplingScientistSignal Transduction PathwaySiteStrategic PlanningStructureTherapeuticTimeTranslational ResearchTumor Suppressor GenesWorkbasecohesiondesignexperienceinstrumentinterestmemberneoplastic cellnovelprogramstumor
中文摘要
生长控制计划创建于2001年,是纽约大学癌症研究所重组的一部分。
院在组织该计划的最初阶段,我们发现有共同领导人帕加诺博士是有益的。
还有斯科尔尼克在这一初期之后,不再需要两位领导人的协同努力。
因此,自2003年以来,该方案仅由帕加诺博士领导。造成这种变化的原因之一是,
是最后一个网站访问者的建议,他们认为,
两个领导人的责任。该计划开始时有17名成员。然而,帕加诺博士是
致力于通过扩大其基础,围绕该计划的中心主题创造一个临界质量,
在重要领域制定新举措(例如,实验室研究与翻译的结合
研究和促进基础科学家和临床医生之间富有成效的互动,见章节
8.2.g和8.2.h)。因此,他选择了一个指导委员会(见下文),以征求新成员。的
指导委员会决定把重点放在候选成员科学地位以外的问题上,
寻找真正为该计划的目标做出具体贡献的调查人员,
将超过50%的时间用于该计划的科学主题。根据多项战略规划
会议期间,招募了更多的科学家,他们的专业知识将促进该计划的目标。这
纽约大学国际学院新的教师招聘工作也推动了增长。目前,该计划
包括44名成员,其中18名(41%)是初级教员。重要的是,17名成员国
2002年后,纽约大学招收了39%的学生(详见下表)。超常规增长
该计划在过去四年中经历了一个重要的过渡时期,
预计将最大限度地提高方案的一致性,促进研究互动。所使用的标准
选择征求和主动申请的成员在增长控制计划包括:1)
在基础和转化癌症相关研究方面表现出的承诺、专业知识和资金; 2)
在这些领域与其他调查人员持续合作的证据; 3)致力于
生长控制计划和纽约大学癌症研究所作为一个整体的共同目标; 4)资金来自
NCI或同等国家组织,用于同行评审、癌症相关和治疗发起
研究(初级研究者除外)。审查生长控制计划的成员资格
指导委员会每年。未能参加计划活动的成员
前一年的人有机会辞职或增加参与。
英文摘要
The Growth Control Program was created in 2001 as part of the reorganization of the NYU Cancer
Institute. In the initial phase of organizing the Program, we found it useful to have co-leaders, Drs. Pagano
and Skolnik. After this initial period, the synergetic exertion by two leaders was no longer necessary.
Accordingly, since 2003 the Program has been led only by Dr. Pagano. Among the reasons for this change
was the recommendation of the last site visitors who concluded that there was undesirable overlap in
responsibilities with two co-leaders. The program started with 17 members. However, Dr. Pagano was
committed to creating a critical mass around the central theme of the program by broadening its base and
developing new initiatives in important areas (e.g., the integration of bench research with translational
research and the promotion of productive interactions between basic scientists and clinicians, see sections
8.2.g and 8.2.h). Therefore, he selected a Steering Committee (see below) to solicit new members. The
Steering Committee decided to focus on issues beyond the scientific stature of the candidate members,
seeking investigators who would truly make a concrete contribution to the objectives of the Program and
devote >50% of their time to the scientific themes of the Program. Following several strategic planning
sessions, additional scientists whose expertise would advance the program's objectives were enrolled. This
growth was also fueled by the new faculty recruitment efforts of the NYUCI. Currently, the program
includes 44 members of which 18 (41%) are junior faculty members. Importantly, 17 members of the
program (39%) were recruited to NYU after 2002 (see details in the Table below). The extraordinary growth
that the Program has experienced in the last four years represents an essential transition period that is
expected to maximize programmatic cohesion and foster research interactions. The criteria used for
selecting solicited and unsolicited applications for membership in the Growth Control Program include: 1)
Demonstrated commitment, expertise and funding in basic and translational cancer-relevant research; 2)
Evidence of ongoing collaborative efforts with other investigators in these areas; 3) Commitment to the
shared objectives of the Growth Control Program and the NYU Cancer Institute as a whole; 4) Funding from
NCI or equivalent national organization for peer-reviewed, cancer-relevant and investigator-initiated
research (junior investigators excluded). The membership of the Growth Control Program is reviewed
annually by the Steering Committee. Members who fail to participate in the program activities during the
previous year are presented with an opportunity to resign or increase their participation.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Regulation of the cell proliferation by CRL ubiquitin ligases
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批准号:10590637
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项目类别:
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资助金额:$33.9万
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财政年份:2020
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负责人:MICHELE PAGANO
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依托单位:
Regulation of the cell proliferation by CRL ubiquitin ligases-diversity supplement
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负责人:MICHELE PAGANO
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依托单位:
Regulation of the cell proliferation by CRL ubiquitin ligases
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批准号:10725087
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资助金额:$9.79万
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财政年份:2020
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负责人:MICHELE PAGANO
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依托单位:
Regulation of the cell proliferation by CRL ubiquitin ligases
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批准号:10379088
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资助金额:$33.9万
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依托单位:
Regulating centrosome homeostasis through the UPS
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批准号:9178269
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负责人:MICHELE PAGANO
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依托单位:
F-box proteins: deregulated cell cycle control and proteolysis in cancer
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负责人:MICHELE PAGANO
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依托单位:
Role of the SCF/FBX011 ubiquitin ligase in the control of cell proliferation
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批准号:8325492
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项目类别:
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财政年份:2011
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负责人:MICHELE PAGANO
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依托单位:
Role of the SCF/Fbxo15 ubiquitin ligase in stem cells and cancer biology
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批准号:8274655
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项目类别:
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资助金额:$18.38万
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财政年份:2011
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负责人:MICHELE PAGANO
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依托单位:
Role of the SCF/Fbxo15 ubiquitin ligase in stem cells and cancer biology
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批准号:8168513
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项目类别:
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资助金额:$22.05万
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财政年份:2011
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负责人:MICHELE PAGANO
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依托单位:
Role of the SCF/FBX011 ubiquitin ligase in the control of cell proliferation
-
批准号:8513435
-
项目类别:
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资助金额:$5.08万
-
财政年份:2011
-
负责人:MICHELE PAGANO
-
依托单位:
Role of the SCF/FBX011 ubiquitin ligase in the control of cell proliferation
-
批准号:8152909
-
项目类别:
-
资助金额:$6.05万
-
财政年份:2011
-
负责人:MICHELE PAGANO
-
依托单位:
Novel Substrates of SCF Ubiquitin Ligases in Cell Cycle Control and Cancer
-
批准号:7188295
-
项目类别:
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资助金额:$16.9万
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财政年份:2006
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负责人:MICHELE PAGANO
-
依托单位:
Novel Substrates of SCF Ubiquitin Ligases in Cell Cycle Control and Cancer
-
批准号:7382542
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项目类别:
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资助金额:$20.3万
-
财政年份:2006
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负责人:MICHELE PAGANO
-
依托单位:
EXPRESSION OF CELL CYCLE PROTEINS IN BREAST CANCER
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批准号:2696380
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项目类别:
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资助金额:$24.02万
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财政年份:1998
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负责人:MICHELE PAGANO
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依托单位:
F box Proteins and Deregulated Proteolysis in Cancer
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批准号:6574895
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项目类别:
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资助金额:$3.36万
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财政年份:1998
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负责人:MICHELE PAGANO
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依托单位:
Regulation of the G1 Phase by the Ubiquitin Pathway
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批准号:6881181
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项目类别:
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财政年份:1998
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依托单位:
Regulation of the cell cycle by SCF and APC/C ubiquitin ligases
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批准号:8106860
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项目类别:
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财政年份:1998
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依托单位:
Regulation of the cell cycle by SCF and APC/C ubiquitin ligases
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批准号:7258645
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项目类别:
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财政年份:1998
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负责人:MICHELE PAGANO
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依托单位:
F-box proteins: deregulated cell cycle control and proteolysis in cancer
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批准号:7258343
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项目类别:
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资助金额:$45.87万
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财政年份:1998
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负责人:MICHELE PAGANO
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依托单位:
Regulation of the cell cycle by SCF and APC/C ubiquitin ligases
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批准号:8451514
-
项目类别:
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资助金额:$44.01万
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财政年份:1998
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负责人:MICHELE PAGANO
-
依托单位:
国内基金
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依托单位:
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依托单位: