Cancer Center Support Grant

描述(由申请者提供)：本次续签申请要求为希望之城综合癌症中心第25至29年的NCI癌症中心资助拨款。该中心目前有五个研究计划：一个基础研究计划(癌症生物学，CB)；三个临床/转化性研究计划(发展癌症治疗，DCT；癌症免疫治疗，CL；恶性血液病，HM)；以及一个人口研究计划(癌症控制和人口科学，CCPS)。12个共享资源支持成员的科学活动，包括两个新的核心(小动物成像；临床免疫生物学相关研究实验室)。提出了三个正在开发的核心(高通量筛选；合成与生物聚合物化学；调查研究)。在前一计划期间，会员人数增加了45%，招募了37名新的正式会员，其中包括几名关键的高级领导人(理查德·乔夫博士，副主任；R.Figlin，医学博士，临床研究副主任)。其他关键领导职位也是通过内部任命来填补的(人口研究的Smita Bhatia博士、公共卫生硕士、人口研究助理；信息科学的Joyce Nland博士、博士；以及翻译研究的Yun Yen博士、博士、副学士)。由于我们的计划重组、招募和基础设施发展，我们现在相信我们有一个中心，其中我们的五个计划代表着一个连续统一体，在这个中心中，基础科学计划CB和一个临床计划DCT的基础和翻译研究可以与所有三个临床计划(DCT、CL、HM)的I期和II期临床方案以及人口科学计划(CCPS)中关于生存和症状管理的后续研究联系起来。所有这些活动都是由一个中心和机构基础设施使之成为可能的，该中心和机构基础设施以非凡的合作方式支持基础和转化性研究，包括生物学和现在的小分子癌症方法。这样的互动导致了该中心的第一个孢子--淋巴瘤；最近获得了W.M.凯克基金会的奖项；以及八个大型、多研究者奖项的续展。在下一个资助期，我们将在这些成就的基础上再接再厉，使希望之城综合癌症中心迈出下一步：将更多的实验室发现转化为创新的临床试验，并开发基于疾病的研究项目。该中心项目的82名正式成员和90名准成员自上次竞争性拨款审查以来已发表了1001篇文章、书籍章节等。其中28%是方案内出版物，22%是方案间出版物。

DESCRIPTION (provided by applicant): This renewal application requests funding for the 25th through 29th years of the NCI Cancer Center Support Grant of the City of Hope Comprehensive Cancer Center. The Center now has five research programs: one basic research Program (Cancer Biology, CB); three clinical/translational research Programs (Developmental Cancer Therapeutics, DCT; Cancer Immunotherapeutics, Cl; Hematologic Malignancies, HM); and one population research program (Cancer Control and Population Sciences, CCPS). Twelve shared resources support the scientific activities of the members, including two new cores (Small Animal Imaging; Clinical Immunobiology Correlative Studies Laboratory). Three developing cores are proposed (High Throughput Screening; Synthetic & Biopolymer Chemistry; Survey Research). Membership has grown by 45% in the preceding program period with the recruitment of 37 new Full Members, including several key senior leaders (Richard Jove, PhD, Deputy Director; R. Figlin, MD, Associate Director [AD] for Clinical Research). Other key leadership positions have also been filled through internal appointments (Smita Bhatia, MD, MPH, AD for Population Research; Joyce Niland, PhD, AD for Information Sciences; and Yun Yen, MD, PhD, AD for Translational Research). As a result of our program restructuring, recruitment and infrastructure development, we now believe we have a Center where our five Programs represent a continuum in which basic and translational studies in the basic science Program, CB, and one clinical Program, DCT, can be linked to Phase I and II clinical protocols in all three clinical programs (DCT, Cl, HM) and follow-up studies in survivorship and symptom management in the population sciences program (CCPS). All these activities are made possible by a Center and Institutional infrastructure that supports basic and translational research in biological and, now, small molecule approaches to cancer in an extraordinarily collaborative fashion. Such interaction has resulted in the Center's first SPORE, in lymphoma; a recent W.M. Keck Foundation award; and the renewal of eight large, multi-investigator awards. During the next funding period, we will build on these achievements so that the City of Hope Comprehensive Cancer Center takes the next step in its evolution: translating more laboratory discoveries into innovative clinical trials and developing disease-based research programs. The 82 Full Members and 90 Associate Members of the Center Programs have published 1001 articles, book chapters, etc., since the last competitive grant review. Of these, 28% are intraprogrammatic and 22% are interprogrammatic publications.