Implantable PV ECG Telemetry System

项目概述/摘要：本项目将开发一种用于小鼠的完全植入式遥测压力传感器。随着许多疾病的遗传基础正在被探索，转基因小鼠在研究应用中越来越重要。由于遗传影响可能很小，因此连续的生理数据采集变得非常重要。例如，来自有意识的正常小鼠的遥测信息导致了子痫前期小鼠模型的发展（28）。第二阶段工作的具体目标是：a)应用专用集成电路（ASIC）的小型化，b.脉冲位置调制软件的开发，c.图形用户界面（GUI）软件的开发，d.高保真大气密封压力传感器的开发，e.小鼠啮齿动物的动物研究。在第一阶段开发的电路适合植入大鼠体内。在第二阶段，电路将小型化，电池将被电感供电电容器取代。在几项研究中，原型装置将被植入矮鼠体内。脉冲位置调制（PPM）将用于节约能源和允许小型化。PPM是脉冲载波的调制，其中调制波的每个瞬时样本的值改变脉冲相对于其出现的未填充时间在时间上的位置。换句话说，在传输开始之前获得的传感器数据值作为两个传输脉冲之间的时间间隔发送给接收器。这种数据传输方法是最节能的，因为发射机的时间很短。将开发一个图形用户界面，使研究人员能够选择小鼠数量、数据采集周期和所需频率。温度信息对于电桥补偿是必要的，并且可以作为另一个实验参数。一种完全密封于大气的应变式压力传感器将允许高保真地测量动脉压力。开发工作将寻求消除漂移。我们建议开发一种低质量可植入的遥测固态压力传感器，它比目前可用的设备更小，可以用于小型，多重安置的转基因小鼠。这种装置将促进人类疾病的小鼠模型的发展，特别是那些具有遗传成分的小鼠模型。该装置的改进可用于长期测量人类的子宫、膀胱、眼睛和隔室压力。

DESCRIPTION (provided by applicant): Project Summary/Abstract:This project will develop a completely implantable telemetric pressure transducer for use in mice. Transgenic mice are increasingly important in research applications as the genetic foundations of many illnesses are being explored. Since genetic effects can be small, data acquisition that is continuous and physiological is becoming very important. Telemetric information from a conscious, normal mouse has led, for example, to the development of a mouse model for preeclampsia (28). The specific aims of this Phase II effort are: a) miniaturization of the application specific integrated circuit (ASIC), b. development of pulse position modulation software, c. development of a graphical user interface (GUI) software, d. development of a high-fidelity pressure sensor sealed to atmosphere, and e. animal studies in murine rodents. The circuitry developed in Phase I is suitable for implantation into a rat. In Phase II the circuitry will be miniaturized and the battery will be replaced with an inductively powered capacitor. The prototype device will be implanted into dwarf rats in several studies. Pulse Position Modulation (PPM) will be used to conserve energy and permit miniaturization. PPM is the modulation of a pulse carrier wherein the value of each instantaneous sample of a modulating wave varies the position in time of a pulse relative to its unpopulated time of occurrence. In other words, the sensor data value that is acquired before transmission starts is sent to the receiver as a time interval between two transmissions pulses. This method of data transmission is the most energy efficient since the transmitter on time is very short. A graphical user interface will be developed to enable researchers to select the number of mice, period of data acquisition and frequencies desired. Temperature information is necessary for bridge compensation and will be available as another experimental parameter. A strain gauge pressure transducer completely sealed to atmosphere will permit high-fidelity measurement of arterial pressures. The development effort will seek to eliminate drift. Project Narrative we propose to develop a low mass implantable telemetric solid-state pressure sensor that is smaller than currently available devices, which can be used in small, multiply housed transgenic mice. Such a device would facilitate development of mouse models of human disease, especially those with a genetic component. Modifications of this device could be used to chronically measure uterine, bladder, eye and compartment pressures in humans.