BIOSTATISTICS CORE

生物统计学核心的作用是支持白血病赠款的研究人员进行研究， 包括实验室实验，以及临床试验的设计和分析。在临床前研究中，CORE 成员将协助制定实验设计，并分析和解释 研究结束时的数据。在临床试验设计阶段，一名核心成员将协助负责人 研究人员正在制定一项临床方案。在临床试验结束时，数据分析将 评估议定书中规定的主要和次要终点的结果。此外, 将进行回顾性数据分析，以解决特定的临床研究问题。如果当前 统计方法论没有充分解决这笔赠款中的一个研究问题 将探索方法论。。 生物统计核心的具体目标是： 1.为实验室研究的设计和分析作出贡献； 2.协助设计和分析临床研究；- 3.发展有助于推进白血病癌症研究的统计方法。 相关性：生物统计学核心对临床前的设计、持续审查和最终分析至关重要 将生物学问题转化为可实验验证的假说的实验和临床试验 产生可解释的结果，并确保计划的临床试验是可行的，引用适当的设计 和停车规则，以确保安全，并得到适当的分析和解释。

The role of the biostatistics core is to support the investigators of this leukemia grant in their research efforts, including laboratory experiments, and the design and analysis of clinical trials. In preclinical studies, core members will assist in the formulation of the experimental design and in the analysis and interpretation of the data at the conclusion of the study. In the clinical trial design phase, a core member will assist the principal investigator in the development of a clinical protocol. At the conclusion of the clinical trial, data analyses will be performed to assess outcomes of the primary and secondary endpoints stated in the protocol. In addition, retrospective data analyses will be performed to address specific clinical research questions. If the current statistical methodology does not adequately address a research question in this grant, alternative methodologies will be explored. . The specific aims of the Biostatistics Core are to: 1. contribute to the design and analysis of the laboratory studies; 2. contribute to the design and analysis of the clinical studies; - 3. develop statistical methodology that will assist in the advancement of leukemia cancer research. Relevance: The Biostatistics Core is essential to the design, ongoing review and final analysis of preclinical experiments and clinical trials to translate biological questions into experimentally testable hypotheses yielding interpretable results and to insure that planned clinical trials are feasible, invoke appropriate design and stopping rules to insure safety and are appropriately analyzed and interpreted.