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Molecular characterisation of early precursor lesions of a novel ñserrated pathwayî of colorectal cancer using gene expression and proteomics.

Molecular characterisation of early precursor lesions of a novel ñserrated pathwayî of colorectal cancer using gene expression and proteomics.
使用基因表达和蛋白质组学对结直肠癌新型“锯齿状通路”的早期前体病变进行分子表征。
批准号:
nhmrc : 1012157
负责人:
A/Pr Andrew Ruszkiewicz
金额:
$21.23万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2011
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2011-01-01 至 2013-12-31

项目摘要

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中文摘要
翻译
在澳大利亚,CRC是所有癌症相关死亡的第二大原因。如果早期发现,CRC有很高的治愈率,但一定比例的前驱病变无法被发现,并显示出进展为CRC的积极临床行为。这些都是很难诊断与现有的技术。我们的目标是了解无蒂锯齿状腺瘤途径背后的生物学,从而提高早期检测,诊断和治疗策略。
英文摘要
In Australia, CRC is the second highest cause of all cancer-related deaths. If detected early, CRC has a high success rate of cure, but a percentage of precursor lesions escape detection and show aggressive clinical behaviour to progress to CRC. These are difficult to diagnosis with existing technologies. We aim to understand the biology behind sessile serrated adenoma pathways and hence enhance early detection, diagnosis and treatments strategies.
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Defining the function of ROCK in establishing a tumour-promoting microenvironment
  • 批准号:
    nhmrc : 1103712
  • 项目类别:
    Project Grants
  • 资助金额:
    $41.93万
  • 财政年份:
    2016
  • 负责人:
    A/Pr Andrew Ruszkiewicz
  • 依托单位:
Defining the function of ROCK in establishing a tumour-promoting microenvironment
  • 批准号:
    nhmrc : GNT1103712
  • 项目类别:
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  • 资助金额:
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  • 财政年份:
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  • 负责人:
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  • 依托单位:
Validation of a multiplexed blood based screening assay for the diagnosis of colorectal cancer
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  • 项目类别:
    Development Grants
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  • 财政年份:
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Regulation of the actin cytoskeleton by miR-200
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  • 项目类别:
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  • 资助金额:
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  • 财政年份:
    2011
  • 负责人:
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海外基金