Clinical Trials Network: Pacific Northwest Node

描述(由申请人提供)：这是太平洋西北(PNW)节点的竞争性续签申请，该节点于2001年1月加入NIDA国家药物滥用治疗临床试验网络(CTN)。我们的主要目标是继续积极支持CTN的使命，通过在严格的多地点临床试验中对行为、药理学和综合行为-药理学治疗干预措施进行研究，以确定其在广泛的CTP环境和多样化的患者群体中的有效性，并确保将研究结果转移到治疗提供者，从而提高全国药物滥用治疗的质量。为了有效地实现这些目标，(PNW)节点建议：在研究人员、治疗提供者和政策制定者之间保持有效的双向伙伴关系和工作关系；在节点内保持和扩大高度成功和成熟的治疗研究基础设施；通过纳入阿拉斯加的基于社区的治疗计划(CTP)来扩大节点的地理覆盖范围，同时扩大节点内的种族多样性；通过增加更大的、具有高度研究经验的CTP来增强节点进行药物治疗试验的能力并更快地对新出现的公共卫生优先事项做出反应；通过增加一些附属研究人员，扩大和深化Node的临床研究专业知识，他们带来了与CTN直接相关的主题领域先前干预试验的丰富经验。在过去的6年里，我们成功地为CTN的使命做出了贡献，并期待在未来继续这样做。从公共卫生的角度来看，我们作为CTN的一部分继续成功地进行此类研究和传播，将有助于在社区治疗计划中实施经验性、循证的干预措施，从而提高药物滥用治疗的质量和有效性。

DESCRIPTION (provided by applicant): This is a competing renewal application for the Pacific Northwest (PNW) Node, which joined the NIDA National Drug Abuse Treatment Clinical Trials Network (CTN) in January, 2001. Our primary aim is to continue our active support of the CTN's mission, to "improve the quality of drug abuse treatment throughout the country using science as the vehicle" by conducting studies of behavioral, pharmacological, and integrated behavioral-pharmacological treatment interventions in rigorous, multi-site clinical trials to determine their effectiveness across a broad range of CTP settings and diversified patient populations and ensuring the transfer of research results to treatment providers. In order to effectively meet these objectives, the (PNW) Node proposes to: Maintain an effective, bidirectional partnership and working relationship among researchers, treatment providers, and policy makers; Maintain and expand a highly successful and well-established treatment research infrastructure within the Node; Expand the Node's geographical reach by incorporating a community-based treatment program (CTP) from Alaska, also broadening the ethnic diversity within the Node; Enhance the Node's capacity to conduct pharmacotherapy trials and respond more rapidly to emerging public health priorities by adding a larger, highly research-experienced CTP; Broaden and deepen the clinical research expertise of the Node by adding a number of affiliated investigators who bring a wealth of experience from prior intervention trials on topic areas directly relevant to the CTN. We have successfully contributed to the CTN's mission over the past 6 years and anticipate continuing to do so in the future. From a public health perspective, our continued success in conducting such research and dissemination as part of the CTN will facilitate empirically supported, evidence-based interventions being implemented in community-based treatment programs, with a resultant improvement in the quality and effectiveness of substance abuse treatment.