Claude D Pepper Older Americans Independence Center at Yale

描述（由申请人提供）：耶鲁老年美国人独立中心（OAIC）成立于1992年，旨在继续为旨在提高独立性的老龄化研究提供智力领导和创新。我们的统一主题仍然是对多因素老年健康状况的调查，包括由多个因素引起的单一状况，或影响多个结果域和同时发生的多种状况。我们的前提是，老年人常见的健康状况是由多种易感因素和诱发因素共同发生的。这些条件和因素反过来又影响到一系列健康领域。诱发因素可能是遗传、生理（损伤）、疾病或社会人口水平，而诱发因素可能是行为、环境、社会、医学或心理。耶鲁OAIC研究的独特之处在于其目的是调查多种因素之间的相互作用，或同时干预多种因素，并衡量条件或干预措施对一系列健康领域的影响。耶鲁大学老年医学协会的目标是：1)培养未来老年医学学术领袖的职业生涯；2)培训调查员和方法学家设计、开展和分析多因素老年健康状况研究所需的技能；3)开发设计和分析技术，用于开展多因素老年健康状况的研究；4)制定战略，在OAIC研究中招募和留住广泛的老年人，包括少数民族；5)从多因素研究的角度探讨老年人健康状况的病因机制，并确定有效的治疗方法；6)制定用于调查多因素老年健康状况和研究多种并存疾病的老年人的结果指标；7)促进基础、转化和跨学科的研究，这些研究与我们对多因素老年健康状况的关注有关。耶鲁大学OAIC的核心包括：1)领导/行政；2)科研职业发展；3)飞行员/探索性;5)生物统计学;6)数据管理/信息学；和7)场。在下一个周期的头几年，我们建议支持4个RCDC候选人；4项试点研究（包括2项RCDC候选研究）；1计算生物学发展研究；14个外部资助项目。

DESCRIPTION (provided by applicant): Established in 1992, the Yale Older Americans Independence Center (OAIC) seeks to continue providing intellectual leadership and innovation for aging research that aims to enhance independence. Our unifying theme remains the investigation of multifactorial geriatric health conditions, encompassing single conditions resulting from multiple contributing factors or affecting multiple outcome domains and multiple conditions occurring simultaneously. Our premise is that health conditions common in older adults are determined by the co-occurrence of multiple predisposing and precipitating factors. These conditions and factors, in turn, affect a range of health domains. The predisposing factors may be at genetic, physiologic (impairment), disease, or socio-demographic levels, while the precipitating factors may be behavioral, environmental, social, medical, or psychological. What distinguishes Yale OAIC research is that its purpose is to investigate the interactions among, or intervene on, multiple factors simultaneously and to measure the effect of conditions or interventions on a range of health domains. The Aims of the Yale OAIC are to: 1) develop the careers of future academic leaders in aging/geriatrics;2) train investigators and methodologists in the skills necessary to design, conduct, and analyze studies of multifactorial geriatric health conditions; 3) develop design and analytic techniques for conducting studies of multifactorial geriatric health conditions; 4) develop strategies for recruiting into, and retaining, a broad spectrum of older adults, including minorities, into OAIC studies; 5) investigate the causative mechanisms of, and identify effective treatments for, health conditions experienced by older adults from a multifactorial research perspective; 6) develop outcome measures for use in investigating multifactorial geriatric health conditions and for studying older adults with multiple coexisting conditions; and 7) facilitate basic, translational, and interdisciplinary research that connects to our focus on multifactorial geriatric health conditions. The Yale OAIC cores include: 1) Leadership / Administrative; 2) Research Career Development; 3) Pilot/Exploratory; 5) Biostatistics; 6) Data Management / Informatics; and 7) Field. For the first years of the next cycle, we propose to support 4 RCDC candidates; 4 pilot studies (including 2 by RCDC candidates); 1 computational biology development study; and 14 externally funded projects. PROGRAM AS A WHOLE