NUTRITION AND ANABOLIC INTERVENTIONS IN CANCER CACHEXIA

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 在世界范围内，估计每年约有200万人死于癌症相关恶病质(肌肉萎缩)的后果。旨在改善瘦体重的新的有针对性的合成代谢疗法显然是必要的。我们的假设是，睾酮的合成代谢特性将通过增加肌肉蛋白质合成和抑制肌肉蛋白分解的激活来增加复发宫颈癌患者的瘦肉量。我们的目标是确定癌症导致骨骼肌蛋白丢失的潜在机制，并检查睾酮治疗是否可以克服这些分子因素的影响。所有受试者都将每月进行DEXA、MRI、肌肉力量测试以及一系列情绪和生活质量评估(在治疗前以及在1、2和3轮化疗后)。所有受试者都将参加一项稳定的同位素研究，以了解他们在基线和3轮化疗后的肌肉蛋白质周转情况。此外，受试者将完成食物日记，并佩戴Actigraph加速计(Actigraph，LLC)来评估每周的活动水平。这项研究将使我们更好地了解癌症恶病质导致肌肉质量丧失的机制，这将为开发有效的治疗方法来改善所有类型癌症相关恶病质的瘦肌肉质量奠定基础。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Worldwide, it is estimated that approximately 2 million people will die annually due to the consequences of cancer-related cachexia (muscle wasting). New targeted anabolic therapies aimed at improving lean body mass are clearly needed. Our hypothesis is that testosterone's anabolic properties will enhance lean muscle mass in patients with recurrent cervical carcinoma by increasing muscle protein synthesis and by inhibiting the activation of muscle proteolysis. Our goals are to determine the mechanisms underlying the cancer-induced loss of skeletal muscle protein and examine whether testosterone treatment can overcome the influence of these molecular factors. All subjects will perform a monthly DEXA, MRI, muscle strength tests and a series of Mood and Quality of Life assessments (before treatment and after 1, 2, and 3 rounds of chemotherapy). All subjects will participate in a stable isotope study of their muscle protein turnover at baseline and again after the 3 rounds of chemotherapy. Additionally, subjects will complete food diaries and wear an ActiGraph accelerometer (ActiGraph, LLC) to assess activity levels each week. This study will allow us to better understand the mechanisms underlying the loss of muscle mass with cancer cachexia, which will serve as a basis to develop effective treatments for improving lean muscle mass in all types of cancer-related cachexia.