ESTRADIOL EFFECT ON BRAIN ACTIVIATION TO EMOTIONAL STIMULI IN OLDER WOMEN

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 一些研究表明，绝经后妇女服用雌激素可能会改变暴露在心理社会压力或情感刺激下的情绪。本研究将探讨雌激素对情绪及相关脑活动的影响。这包括注射雌激素，然后在情绪唤醒测试中使用一种名为功能磁共振成像(FMRI)的技术来检测大脑激活的区域。受试者将包括20名绝经后妇女，年龄50岁以上，随机服用雌激素或安慰剂，为期三个月。在随机化前后，受试者将在fMRI扫描仪中进行负面情绪唤醒测试，在此期间，他们看到负面和中性的单词和图片，并被要求观看、记忆和主观评价刺激的厌恶程度。这将帮助我们确定雌激素是否会在主观上和大脑水平上改变你对情绪刺激的反应方式。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Some studies have suggested that estrogen administration in postmenopausal women may alter mood after exposure to psychosocial stress or emotional stimuli. This study will investigate the effects of estrogen on emotion and associated brain activity. This involves administering estrogen and then detecting areas of brain activation during an emotional arousal test using a technique called functional magnetic resonance imaging (fMRI). Subjects will consist of 20 postmenopausal women, age 50+, randomized to either estrogen or placebo for three months. Before and after randomization subjects will perform a negative emotional arousal test in the fMRI scanner, during which they see negative and neutral words and pictures and are asked to look at, remember and subjectively rate the aversiveness of the stimuli. This will help us determine if estrogen administration changes the way you respond to emotional stimuli both subjectively and at the level of the brain.