Improving the Bryan Vivarium in Support of the Rodent Imaging Core

描述（由申请人提供）：杜克的动物设施支持由公共卫生服务（PHS）和非PHS来源资助的动物相关的研究和教学。NCRR支持杜克的中心在体内显微镜的（CIVM）与动物研究有关的成像工作，作为国家生物医学技术资源中心。CIVM是NCRR最大的资助成像资源，是NCI小动物成像资源计划。CIVM包括MRI、微型CT/微型X射线、超声、成像生物支持、超极化气体偏振器、计算机/网络/可视化工具、线圈光刻/蚀刻和高纵横比指状线圈T-tech研磨机。数据库向世界各地的机构提供基于动物的成像信息。2008年3月，CIVM参与了44个内部和外部项目，CIVM的年度小动物成像研讨会每次会议吸引了100多名参与者。 CIVM在布莱恩研究大楼的一楼，CIVM动物在地下室动物设施。目前，由于机构检疫政策，该中心对来自不同机构的动物进行纵向研究的能力有限。此外，缺乏消毒能力限制了免疫缺陷啮齿动物或生物危险材料的CIVM使用。设施现代化将使CIVM能够扩大能力。 申请的目的是：（1）更换陈旧的笼式洗衣机，并增加一个高压灭菌器，以支持更广泛的啮齿动物住房;（2）增加一个生物安全柜，为外科手术和危险制剂提供保护区;（3）通过拆除隔离墙，提供更多的住房能力;重新装修所有楼层;（4）提供通风架和动物转移站，以减少疾病传播的可能性; 5）扩大自动供水，提高运行效率; 6）建立清洁-肮脏走廊系统，保持动物健康状态。

DESCRIPTION (provided by applicant): Duke's animal facilities support animal-related research and teaching funded by Public Health Service (PHS) and non-PHS sources. NCRR supports Duke's Center for In Vivo Microscopy's (CIVM) imaging efforts related to animal research as a National Biomedical Technology Resource Center. CIVM is NCRR's largest funded imaging resource, and is a NCI Small Animal Imaging Resource Program. The CIVM includes MRI, micro-CT/micro x-ray, ultrasound, imaging biological support, hyperpolarized gases polarizer, computers/network/visualization tools, coil lithography/etching, and high-aspect finger coils T-tech mill. Databases provide animal-based imaging information to institutions world-wide. March 2008 showed CIVM in forty-four projects both internal and external, and CIVM's annual Small Animal Imaging Workshop attracts 100+ participants per session. CIVM is on the first floor of the Bryan Research Building, CIVM animals are in the basement animal facility. Currently, the Center has limited ability to perform longitudinal studies with animals from various institutions due to institutional quarantine policies. Also, lack of sterilization capabilities limits CIVM use of immunodeficient rodents or bio-hazardous materials. Facility modernization will allow CIVM to expand capabilities. The application objectives are: 1) Replace the antiquated cage washer and add an autoclave to support wider varieties of rodent housing; 2) add a bio-safety cabinet, providing protected areas for surgical procedures and hazardous agents; 3) Provide more housing capabilities by removing isolation cubicles; re-do all floors; 4) Provide ventilated racks and animal transfer stations to lessen disease transmission possibilities; 5) extend automatic watering for more efficient operation; 6) establish a clean-dirty corridor system to maintain animal health status.