Appalachian Tri-State NODE

此申请是对RFA DA-05-001加入美国国家药物滥用研究所(NIDA)的回应 临床试验网络(CTN)作为阿巴拉契亚三州(ATS)节点与其他CTN节点合作 在社区进行多点临床试验。ATS将服务于一个重要的地理区域，有许多 农村和未得到充分服务的人口。该节点包括西方精神病学研究所的一个研究小组和 匹兹堡大学医学中心诊所(WPIC)与五个社区治疗机构合作 西弗吉尼亚州、俄亥俄州东部和宾夕法尼亚州西部的供应商(CTP)。临床的异质性 在这些CTP中服务的人群将允许CTP进行疗效和有效性试验 提供者和临床人群的范围。ATS节点的组成包括：(1)有经验的团队 农村和城市地区的CTP为多种药物滥用临床中的不同患者群体提供服务 每年接触13,000多名患者的计划；(2)在 WPIC的区域研究治疗中心(RRTC)，用于进行行为、药物治疗和 结合临床试验和相关活动；(3)强大的培训和教育部分，可以提供 研究和临床培训并传播研究成果；(4)协调管理机构 ATS节点组件之间的活动，并促进内部的最佳沟通与合作 节点以及与NIDA和国家CTN的合作；以及(5)技术转让、培训和 传播活动。RRTC和CTP在过去四年中合作建立了一个 基础设施，建立双向通信，并进行两项试点研究。 我们的目标是：(1)发展和维护参与临床试验的CTP区域网络，(2) 为国家CTN开发、指导和参与临床试验，(3)为国家CTN提供信息和培训 为区域治疗提供者提供机会，(4)开发、促进和实施治疗分配 努力；以及(5)促进制定传播以研究为基础的治疗方法 结果，以及将经经验验证的评估和治疗方法整合到正在进行的 社区医疗服务设施的活动。

This application is in response to RFA DA-05-001 to join the National Institute of Drug Abuse's (NIDA) Clinical Trials Network (CTN) as the "Appalachian Tri-State" (ATS) Node to work with other CTN Nodes to conduct multi-site clinical trials in the community. ATS will serve an important geographic area with many rural and underserved populations. This Node includes a research group at Western Psychiatric Institute and Clinic (WPIC) of the University of Pittsburgh Medical Center in partnership with five community treatment providers (CTPs) in West Virginia, Eastern Ohio and Western Pennsylvania. The heterogeneity of the clinical populations served in these CTPs will allow the CTP's to conduct efficacy and effectiveness trials with a range of providers and clinical populations. Components of the ATS Node include: (1) an experienced group of CTPs in rural and urban locations serving diverse groups of patients in many types of drug abuse clinical programs with access to over 13,000 patients annually; (2) an established research infrastructure within the Regional Research Treatment Center (RRTC) at WPIC for conducting behavioral, pharmacotherapy and combined clinical trials and related activities; (3) a strong training and education component that can provide research and clinical training and disseminate research findings; (4) an administrative structure to coordinate activities among the ATS Node components and to promote optimal communication and cooperation within the Node and with NIDA and the National CTN; and (5) a portfolio of technology transfer, training and dissemination activities. The RRTC and CTPs have collaborated during the past four years to build an infrastructure, establish bi-directional communication, and conduct two pilot studies. Our aims are to: (1) develop and maintain a regional network of CTPs to participate in clinical trials, (2) develop, direct, and participate in clinical trials for the National CTN, (3) provide information to, and training opportunities for regional treatment providers, (4) develop, promote, and implement treatment distribution efforts, and (5) contribute to the development of methods for dissemination of research-based treatment findings, and the integration of empirically-validated assessment and treatment methods into the ongoing activities of community healthcare delivery facilities.