MEDICATION DEVELOPMENT FOR COCAINE ABUSERS

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 在本报告所述期间，我们研究了各种可卡因的苯托烷类似物作为可卡因成瘾者的潜在药物。 在过去的一年中，各种3-苯基托烷多巴胺转运蛋白的选择性的合成和性能进行了检查。除了表征这些新化合物外，我们还发现许多这些化合物具有类似精神兴奋剂的特性，这对于我们的目标很重要。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. During the reporting period, we examined a variety of phenyltropane analogs of cocaine as potential medications for cocaine addicts. The synthesis and properties of various 3-phenyltropanes selective for the dopamine transporter were examined in the past year. In addition to characterizing these novel compounds, we have shown that many of these compounds have psychostimulant-like properties, which is important given our goal.