Career Development and Mentoring in Clinical/Translational Alcohol Research

描述（由申请人提供）：高级科学家研究和指导奖是针对“在生物医学研究中表现出持续高生产力水平的杰出高级科学家”的，目的是保护他们继续研究的时间，同时指导下一代研究者。拥有超过20年的临床酒精研究经验[超过20个临床试验，在渴望（OCDS），饮酒生物标志物（CDT）和神经影像学方面的开创性工作]，15年持续的R01资助，12年担任酒精研究中心的科学主任，180同行评审出版物和国际认可，候选人符合杰出资深科学家的要求。他被选为领先学术和研究协会的高级领导职位，担任指导委员会的同行选举主席，指导大型，多中心NIH/NIAAA资助的临床试验（COMBINE研究），研究了1383名酒精依赖个体，并因其独特的技能，知识和能力而被视为专家，以弥合基础和临床研究之间的差距。在完成这些工作的同时，他还积极参与酒精研究的培训项目，包括担任niaaa赞助的T32研究培训基金的主任或联合主任20年。他指导了17名专业人士（12名医学博士和5名博士），许多人因为他在基础科学和临床科学之间的桥梁方面的专业知识而寻求他，许多人获得了独立的酒精研究资金，所有人都与酒精领域保持联系。他对酒精障碍治疗的机制和应用的理解是非典型的和例外的。该奖项对候选人很重要，主要有两个原因：首先，它将为他提供受保护的时间，使他能够获得遗传学和蛋白质组学的正式和非正式培训，使他的酒精研究事业保持在前沿（职业规划中提供了课程细节），将这些重要的科学领域应用于他自己的酒精研究（如所述），并向酒精治疗领域传达新发现。其次，该奖项将为候选人提供额外的临床和行政职责的保护时间，这样他就可以继续并扩大他积极的指导计划，该计划的重点是培养下一代临床科学家。他从培训中获得的知识和技能将融入并加强他的指导计划。医学研究所和美国医学院协会强调，美国对临床和转化研究人员的巨大需求尚未得到满足，数百万美国人患有酒精障碍，他们得不到充分的服务，每年给美国经济造成1800亿美元的损失，因此有必要推动临床研究向前发展，有必要确保我们的资深科学家走在研究的前沿。而且需要培养未来的科学家来进行这项研究，以找到有效的治疗方法。K05高级科学家职业和指导奖将使这一切成为可能。

DESCRIPTION (provided by applicant): The Senior Scientist Research and Mentorship Award is targeted for "outstanding senior scientists who have demonstrated a sustained level of high productivity conducting biomedical research" in order to protect their time to continue research while mentoring the next generation of investigators. With more than 20 years of experience in clinical alcohol research [over 20 clinical trials, seminal work in craving (OCDS), biomarkers of drinking (CDT), and neuroimaging], 15 years of continued R01 funding, 12 years of serving as Scientific Director of an Alcohol Research Center, 180 peer reviewed publications, and international recognition, the candidate meets the requirements as an outstanding senior scientist. He has been elected to high leadership positions of leading academic and research societies, serves as the peer-elected chairman of the steering committee, directing the large, multi-center NIH/NIAAA funded clinical trial (COMBINE Study) which studied 1383 alcohol dependent individuals, and is sought out as an expert for his unique skill set, knowledge and ability to bridge the gap between basic and clinical research. He has accomplished this while maintaining an active training program in alcohol research, including 20 years as Director or Co-Director of an NIAAA-sponsored T32 Research Training Grant. He has mentored 17 professionals (12 MDs & 5 PhDs), many who sought him out due to his expertise in bridging basic and clinical science, many who have secured independent alcohol research funding, and all who remain tied to the alcohol field. His understanding of both the mechanisms of, and applications to, the treatment of alcohol disorders is atypical and exceptional. This award is important to the candidate for two major reasons: First, it will provide him with protected time to keep his alcohol research career on the cutting edge by enabling him to obtain formal and informal training in genetics and proteomics (course details provided in the career plan), apply these essential areas of science to his own alcohol research (as outlined), and communicate new discoveries to the alcohol treatment field in general. Second, this award will provide the candidate with protected time from additional clinical and administrative duties so he can continue with and expand his active mentoring program which is focused on the development of the next generation of clinical scientists. The knowledge and skills he gains from his training will be integrated into and strengthen his mentoring program. With the Institute of Medicine and the American Association of Medical Colleges highlighting the large, unmet need in the US for clinical and translational researchers and with millions of Americans suffering from alcohol disorders, who are underserved and who cost the US economy $180 billion each year, there is a need to push clinical research forward, a need to ensure our senior scientists are on the cutting edge in their research, and a need to train future scientists to carry on this research to find effective treatments. This K05 Senior Scientist Career and Mentoring Award will allow this to happen.