STUDIES OF AGING AND COGNITION IN NONHUMAN PRIMATES

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 该项目之前的研究已经表征了恒河猴认知能力随年龄的变化。所获得的数据被用作研究大脑变化以及运动功能变化的基础，大脑变化是正常认知能力下降的基础。我们的研究使我们能够表征荷尔蒙和性别相关变量对认知表现的影响，并将单胺受体的变化与认知联系起来。我们考察的基本认知领域包括再认记忆、空间工作记忆和内隐记忆。在资金中断后，这项研究在最后一个项目期间重新开始。幼年恒河猴和老年恒河猴已经被确定为这项研究的对象，我们已经开始通过结构磁共振的方法对动物进行筛查。行为测试还没有进行。随着数据收集的继续，我们预计这项工作将继续澄清哪些神经变化导致认知能力的年龄相关变化，以及哪些神经特征与相对抵抗认知能力下降有关。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Prior studies in this project have characterized age-related changes in cognitive performance in the rhesus monkey. The data obtained have been used as the basis for studies of the changes in the brain which underlie normal cognitive decline, as well as changes in motor function. Our studies have permitted us to characterize the influence of hormonal and sex-related variables on cognitive performance, and to relate changes in monoamine receptors in relation to cognition. The basic cognitive domains we have examined include recognition memory, spatial working memory, and implicit memory. After a break in funding, this study restarted during the last project period. Young and aged rhesus monkeys have been identified for this study and we have begun to screen the animals by means of structural MRI. Behavioral testing is not yet underway. As data collection continues, we expect that this work will continue to clarify which neural changes lead to age-related changes in cognitive ability, and which neural characteristics are associated with relative resistance to cognitive decline.