Sp Base: A Sea Urchin Genome Database

描述(由申请人提供)：拟议项目的总体目标是扩大和扩大一个独特的海胆基因组数据库。该数据库将是一个适度的组织，将海胆研究实验室产生的相关数据纳入海胆基因组测序项目的注释和基因模型中，该项目由贝勒医学院人类基因组测序中心管理，并由海胆基因组注释团队成员进行。它的具体目的是填补在初级注释完成时留下的空白，而其他现有数据库无法合并基因表达数据和其他可与基因组序列和基因模型相联系的特定生物信息。这些数据的立竿见影的用处被发表在《发育生物学和科学》上的大约40份研究报告证明了，这些研究报告是从注释中产生的。其中一份报告描述了一种用于注释和扩展预测基因模型的全基因组拼接阵列。此外，这些出版物中报告的工作包括广泛的手动基因注释、另一种微阵列实验以及从胚胎阶段进行的各种时间和空间基因表达测定。如果没有新数据库的建立，预计大部分实验数据和初级基因组序列之间的联系将随着时间的推移而丢失或严重退化。新的海胆基因组数据库SpBase将以一种适合广泛编辑、更新和安装对使用海胆系统的实验者特别有用的附加功能的结构来积累和维护基因组序列、基因注释和辅助生物信息。这项任务将通过合作有效地完成，使我们能够访问GMOD的软件模块和Wormbase项目的专业知识，Wormbase项目是我们家机构的一个模型生物体数据库。

DESCRIPTION (provided by applicant): The overall goal of the proposed project is to extend and expand a unique genome data base for sea urchins. The database will be a modest organization incorporating relevant data produced by sea urchin research labs into the annotations and gene models emerging from the work of the Sea Urchin Genome Sequencing Project as managed by the Baylor College of Medicine, Human Genome Sequencing Center and pursued by the members of the Sea Urchin Genome Annotation team. It is specifically intended to fill the void left when the primary annotation is finished and other existing databases are not able to incorporate gene expression data and other specific biological information that can be linked to the genome sequence and gene models. The immediate utility of these data is evidenced by the publication of about 40 research reports in Developmental Biology and Science which emerged from the annotation. One of these reports describes a whole-genome tiling-array that was used to annotate and extend the predicted gene models. In addition the work reported in these publications covers extensive manual gene annotations, another microarray experiment and a wide variety of temporal and spatial gene expression determinations from embryonic stages. It is expected the linkages between much of this experimental data and the primary genomic sequences will be lost or severely degraded over time without the inception of a new database. The new sea urchin genome data base, SpBase will accumulate and maintain the genome sequence, gene annotation and ancillary biological information in a structure suitable for extensive editing, updating and installing of additional features that are specifically useful to the experimentalist using the sea urchin system. The task will be efficiently accomplished through a collaboration that gives us access to software modules from GMOD and expertise from the Wormbase project, a model organism database housed at our home institution.