Body Composition and Disability in RA and SLE

本研究的主要目的是评估身体成分在功能发育中的作用。 类风湿性关节炎（RA）和系统性红斑狼疮（SLE）的缺陷和残疾， 一个完善的残疾模式的背景下。使用这种模式将有助于更大的 了解身体成分在残疾发展中的作用，同时考虑到其他因素， 疾病，治疗，人口统计学，心理社会和行为因素，可能有助于或保护 从残疾。这一项目也是首次尝试对残疾人的残疾特征进行分析， SLE在广泛的生活活动中使用“有价值的生活活动”残疾模型。具体目标 目的是：（1）研究身体成分在SLE功能限制和残疾发展中的作用 和RA，使用现有的残疾模型;（2）识别与身体相互作用的风险和保护因素 在功能限制和残疾的发展中，或在功能和 避免残疾，在类风湿关节炎和系统性红斑狼疮;（3）估计残疾的患病率和发病率在广泛的 生活活动的范围在一个大的群体与SLE的个人。拟议研究的受试者将是 现有的UCSF RA小组和狼疮结局研究（LOS）的成员。现有研究方案 包括到2008年每年对同批人进行一次电话访谈， 这个应用程序的方法论核心。拟议的研究将在此基础上，增加具体项目， 措施，以每年的电话采访，并增加了两个人在加州大学旧金山分校一般评估 每个队列的受试者子集的临床研究中心（GCRC）。在GCRC访问期间，我们将 进行身体成分评估，进行肌肉力量和身体功能测试， 获得血液样本用于测量炎症和其他标志物，获得习惯性 身体活动，并进行认知功能评估。分析，结合访谈和家访 数据，将集中在3个主要领域-（1）描述2个队列中的身体组成结果，（2）估计 2个队列中身体成分与功能限制和残疾之间的关系;以及（3） 识别可能改变或调节身体成分与以下两者之间关系的因素： 功能限制或残疾。分析还将确定自我报告的信息之间的相关性 从访谈数据（例如，根据自我报告的身高和体重计算的体重指数）， 从GCRC评估中收集。这项研究的结果将提供有助于 识别可能处于残疾最大风险的RA和SLE患者，并评估 残疾发展的干预因素。

The overarching aim of this study is to estimate the role of body composition in the development of functional imitations and disability in both rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), within the context of a well-established model of disablement. Use of this model will facilitate a greater understanding of the role of body composition in the development of disability, taking into account other disease, therapeutic, demographic, psychosocial, and behavioral factors that may contribute to or protect from disability. This project also represents the first attempt to characterize disability among persons with SLE across a wide range of life activities using the "valued life activities" model of disability. Specific aims are to: (1) examine the role of body composition in development of functional limitations and disability in SLE and RA, using an existing model of disablement; (2) identify risk and protective factors that interact with body composition in the development of functional limitations and disability, or the maintenance of function and avoidance of disability, in RA and SLE; and (3) estimate the prevalence and incidence of disability in a wide range of life activities in a large group of individuals with SLE. Subjects for the proposed study will be members of the existing UCSF RA Panel and Lupus Outcomes Study (LOS). Existing study protocols include annual telephone interviews with the cohorts through 2008, with an additional two years proposed in the Methodology Core of this application. The proposed study will build upon this by adding project-specific measures to the annual telephone interviews, and adding two in-person assessments at the UCSF General Clinical Research Center (GCRC) for a subset of subjects from each cohort. At the GCRC visit, we will conduct an assessment of body composition, conduct testing of muscle strength and physical function, obtain blood samples for measurement of inflammatory and other markers, obtain an estimate of habitual physical activity, and perform a cognitive function evaluation. Analyses, combining interview and home visit data, will focus on 3 major areas - (1) describing body composition findings in the 2 cohorts, (2) estimating the relationship between body composition and functional limitations and disability in the 2 cohorts; and (3) identification of factors that may modify or mediate the relationship between body composition and either functional limitations or disability. Analyses will also identify the correlation between self-reported information from interview data (e.g., body mass index calculated from self-reported height and weight) with that gathered from the GCRC assessment. The findings from this study will provide information that can assist in identifying individuals with RA and SLE who may be at greatest risk of disability, and estimating the effect of intervening factors on the development of disability.