Genetic Determinants of Alcohol Preference & Actions of Drugs of Abuse Component

该项目的长期目标是更好地了解药物的反应和后果， 对基因上容易酗酒的对象进行虐待。这是一个重要的领域， 在酒精领域的研究，因为许多，绝大多数在尼古丁的情况下，个人谁滥用或 依赖酒精也滥用其他药物。此外，有证据表明，尼古丁或可卡因可以 促进酒精复发，并与酒精发生神经生物学相互作用。总的假设是 测试是（1）选择性繁殖不同的酒精饮用也会产生不同的反应， 其他药物滥用的影响，以及（2）先前暴露于其他药物滥用将对 饮酒和酒精的强化作用是受基因影响的。这些假设将 在选择性饲养的酒精偏好（P），酒精非偏好（NP），高酒精饮用 (HAD)和低酒精饮用（LAD）大鼠系。这项建议的目的是研究 尼古丁和可卡因对自发活动、饮酒和强化以及中脑边缘多巴胺的影响 (DA)选择性繁殖的大鼠品系的活性。这项研究的结果将提供重要的信息， 遗传因素如何影响酗酒和滥用其他药物的倾向，以及 影响饮酒的遗传因素会对其他滥用药物产生反应。这些信息可以提供 深入了解可能影响某些人对药物和酒精滥用脆弱性的共同因素 人口。该研究组件与管理和动物管理组件相互作用并依赖于管理和动物管理组件。 生产核心，并与其他大鼠遗传研究组成部分科学地相互作用。这 研究部分符合IARC的主题，因为它正在研究遗传对以下行为的影响： 尼古丁和可卡因改变饮酒和乙醇（EtOH）的强化作用。

The long-range goals of this project are to better understand the response and consequences of drugs of abuse on subjects that are genetically vulnerable to high alcohol drinking. This is an important area of research in the alcohol field, because many, a large majority in the case of nicotine, individuals who abuse or are dependent on alcohol also abuse other drugs. Moreover, there is evidence that nicotine or cocaine can promote alcoholic relapse and have neurobiological interactions with alcohol. The overall hypotheses to be tested are that (1) selective breeding for disparate alcohol drinking will also produce disparate responses to the effects of other drugs of abuse, and (2) prior exposure to other drugs of abuse will have effects on alcohol drinking and the reinforcing effects of alcohol that are genetically influenced. These hypotheses will be tested in the selectively bred alcohol-preferring (P), alcohol-non-preferring (NP), high-alcohol-drinking (HAD) and low-alcohol-drinking (LAD) lines of rats. The objectives of this proposal are to examine the effects of nicotine and cocaine on locomotor activity, alcohol drinking and reinforcement, and mesolimbic dopamine (DA) activity of the selectively bred lines of rats. The results of this study will provide important information on how genetic factors influence a predisposition for high alcohol drinking and abusing other drugs, and how genetic factors that influence alcohol drinking react to other drugs of abuse. Such information could provide insight into common factors that might influence vulnerability to drug and alcohol abuse in certain human populations. This research component interacts with and is dependent upon the Administrative and Animal Production Cores, and also scientifically interacts with the other rat genetic research component. This research component fits within the theme of the IARC in that it is studying genetic effects on the actions of nicotine and cocaine to alter alcohol drinking and the reinforcing effects of ethanol (EtOH).