NIAMS Multidisciplinary Clinical Research Center

描述(由申请人提供)：建议的加州大学旧金山分校多学科临床研究中心计划(UCSF MCRC)的广泛目标是通过发现影响这些结果的医疗、人口和背景因素来改善各种形式的风湿病患者的结果。这一总体目标是通过风湿病临床研究的全面计划来实现的，包括但不限于MCRC内的研究；作为整个加州大学旧金山分校此类临床研究的催化剂；以及对风湿病临床研究人员的系统培训。 MCRC包括一个行政股、方法核心、三个五年期项目和一项为期三年的发展和可行性研究。MCRC的参与者跨越加州大学旧金山分校的三所学校(医学、护理和牙科)和加州大学戴维斯分校，包括加州大学旧金山分校GCRC在内的九个独立学术单位的代表。该中心的主任和副主任分别是爱德华·叶林博士和林赛·克里斯韦尔博士。核心单位主任是Patricia Katz博士。多民族玻利维亚国的活动由一个执行委员会日常指导。该中心的战略监督由内部(加州大学旧金山分校)和外部咨询委员会提供。 MCRC的研究基于对两种特定疾病--系统性红斑狼疮(SLE)和类风湿性关节炎(RA)患者的原始数据的分析，以及对更广泛肌肉骨骼疾病患者的次要数据的分析。具体的五年项目是：“社会人口和遗传因素在系统性红斑狼疮健康差距中的相互作用”；“系统性红斑狼疮与就业：个人和背景因素的影响”；以及“中年肌肉骨骼状况是否会导致老年人的残疾？”D&F研究是：系统性红斑狼疮患者的神经精神症状和MRI标记物。

DESCRIPTION (provided by applicant): The broad aim of the proposed UCSF Multidisciplinary Clinical Research Center Program (UCSF MCRC) is to improve outcomes for persons with various forms of rheumatic diseases by discovery of the medical, demographic, and contextual factors affecting those outcomes. This overarching aim is pursued by a comprehensive program of clinical research in the rheumatic diseases, including but not limited to that within the MCRC; by serving as a catalyst for such clinical research throughout UCSF; and by systematic training of clinical investigators in the rheumatic diseases. The MCRC consists of an Administrative Unit, Methodology Core, three five-year projects, and a three-year Development and Feasibility (D&F) Study. The participants in the MCRC span three UCSF schools (Medicine, Nursing, and Dentistry) and UC Davis and include representatives of nine discrete academic units, including the UCSF GCRC. The Center's Director and Associate Director are Drs. Edward Yelin and Lindsey Criswell, respectively. The Director of the Core Unit is Dr. Patricia Katz. The activities of the MCRC are guided on a day-to-day basis by an Executive Committee. Strategic oversight of the Center is provided by Internal (UCSF) and External Advisory Committees. The research in the MCRC is based on analysis of primary data on persons with two specific diseases, Systemic Lupus Erythematosus (SLE) and Rheumatoid Arthritis (RA), and on analysis of secondary data on persons with a broader array of musculoskeletal conditions. The specific five-year projects are: "The Interplay of Sociodemographic and Genetic Factors in SLE Health Disparities"; "SLE and Employment: The Impact of Individual and Contextual Factors"; and, "Do Mid-Life Musculoskeletal Conditions Lead to Disability in the Elderly?". The D&F study is: Neuropsychiatric Symptoms and MRI Markers in SLE Patients APLA".