PET AND MRI OF MARMOSETS: A PILOT STUDY

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 这项研究的长期目标是使用最先进的，非侵入性的医学成像方法来创建一个4维（空间和时间），多变量的绒猴大脑在整个生命周期的图谱-从出生，通过发展和成熟，衰老-并映射到这些相同的变量在人类的时间配置文件派生变量的时间配置文件。这项工作的动机是促进绒猴作为一种实用的灵长类动物衰老模型的发展。绒猴是最小和寿命最短的新世界猴，平均寿命为-6年。尽管体积很小，但绒猴的大脑非常复杂，所有主要的细胞结构区域都存在于更大，更长寿，更常被研究的灵长类动物中，如猕猴。在这项研究中，我们将进行PET和MR成像的四个常见的绒猴，年龄从1天到5岁，以证明可行性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The long-term objective of this research is to use state-of-the-art, non-invasive, medical imaging methods to create a 4-dimensional (space and time), multi-variable atlas of the marmoset brain across the entire life-span -from birth, through development and maturation, to senescence -and to map the temporal profiles of derived variables into the temporal profiles of these same variables in humans. The motivation for this undertaking is to foster the development of the marmoset as a practical, primate model of aging. The marmoset is the smallest and shortest-lived new-world monkey, with a median life-span of -6 years. Despite its small size, the marmoset brain is remarkably complex, having all the major cytoarchitectonic regions present in larger, longer-lived, more-commonly studied primates, such as the macaque. In this study we will conduct PET and MR imaging on four common marmosets, ranging in age 1 day old to 5 years old, in order to demonstrate feasibility.