AFFECTIVE AND NEUROBIOLOGICAL PREDICTORS OF ADOLESCENT-ONSET ALCOHOL USE DISORDE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项工作的长期目标是解决具有重大临床和社会政策相关性的问题--了解易感性的发展途径和机制，以便为青少年酒精使用障碍(AUD)的早期干预提供信息，特别是针对有情感脆弱性的年轻人的干预。短期目标是测试一个发展模型的关键特征，重点放在选定的遗传、环境、行为和神经生物学因素上，因为它们影响青春期患AUD的风险。该设计包括横断面比较，以及从青春期中期到青春期后期对高和低抑郁家庭负荷的青少年(高-DEP与低_DEP)进行的前瞻性纵向研究。 这项研究的具体目的有四个： 1.探讨抑郁家庭负担对青春期AUD发病风险的影响。 2.研究家族性表达负荷对与情绪和情感相关的潜在神经回路的影响，特别是那些调节行为和生理唤醒和情感控制的神经回路，以及它们与青春期发生AUD的风险的关系。 3.探讨遗传和环境危险因素对青春期AUD发病风险的具体贡献。 4.前瞻性研究AUD对情绪唤醒和控制的神经回路的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The long-term goals of this work are to address questions with great clinical and social policy relevance - understanding developmental pathways and mechanisms of vulnerabiity that can inform early interventions for adolescent-onset alcohol use disorders (AUD), especially those targeting youth with affective vulnerabilities. The short-term goals are to test key features of a developmental model focusing on elected genetic, environmental, behavioral and neurobiological factors as they impact risk for developing AUD during adolescence. The design includes cross-sectional compraisons as well as a prospective longitudinal study of young adolescents with high and low familial loading for depression (HIGH-DEP vs. LOW_DEP) followed from mid to late adolescence. There are four sepcific aims of this research: 1. To examine the impact of familial loading for depression on the risk to develop AUD during adolescence. 2. To examin the effects of familial loading for expression on underlying neural circuits related to mood and affect - especially those mediating behavioral and physiologc arousal and affective control - and their association with the risk to develop AUD duing adolescence. 3. To examine the specific contributions of genetic and environmental risk factors for the risk to develop AUD during adolescence. 4. To examine prospectively the effect of developing AUD on neural circuitry involved in affective arousal and control.