WHI NUTRITIONAL AND PHYSICAL ACTIVITY ASSESSMENT STUDY (NPAAS)

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 营养和体力活动评估研究（NPAAS）将在妇女？的健康倡议（WHI），目前处于IRB方案04-EPID-486的扩展阶段。NPAAS将在年龄、体重和种族方面代表OS女性的绝经后体重稳定女性中进行; 48例研究受试者将在研究中心接受检查（所有参与研究中心为540例）。 除了其他选定的饮食和体力活动评估工具外，参与妇女还将完成与WHI招募筛选时（1993-1998年）相同的食物频率问卷（FFQ）和体力活动问题。 此外，他们将遵循双标记水方案来客观评估总能量消耗，并采用间接热量测定方案来评估静息能量消耗，从而对活动相关能量消耗进行客观评估。 还将评估尿液样本中蛋白质、钠和钾的消耗，并评估血液样本中各种营养素的浓度。 这些数据将用于评估和对比精心挑选的营养素和体力活动评估工具及其组合的测量特性，重点是：作为体重，种族，年龄和其他个体特征的函数的系统偏差;个人特定测量误差的大小;不同评估程序误差之间的相关模式;以及营养消耗和活动相关能量消耗估计的精确度。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Nutrition and Physical Activity Assessment Study (NPAAS) will be conducted within the Observational Study (OS) component of the Women?s Health Initiative (WHI), currently in an extension phase under IRB Protocol 04-EPID-486. The NPAAS will be conducted among postmenopausal weightstable women who are representative of OS women in age, body mass, and ethnicity; 48 study participants will be examined at the UNC center (540 at all participating sites). Participating women will complete the same food frequency questionnaire (FFQ) and physical activity questions used at time of screening for WHI enrollment (1993-1998) in addition to other selected dietary and physical activity assessment instruments. In addition, they will follow a doubly-labeled water protocol to objectively assess total energy expenditure and an indirect calorimetry protocol to assess resting energy expenditure, thus yielding an objective assessment of activity-related energy expenditure. The expenditure of protein, sodium, and potassium will also be assessed from urine specimens, and the concentrations of various nutrients will be assessed in blood specimens. These data will be used to assess and contrast measurement properties of carefully selected nutrients and physical activity assessment tools and their combination, with an emphasis on: systematic bias as a function of body mass, ethnicity, age, and other individual characteristics; the magnitude of personspecific measurement errors; the correlation patterns among errors from differing assessment procedures; and the precision of nutrient consumption and activity-related energy expenditure estimates.