ARIC CLINICAL EXAMINATION CENTER

ARIC临床检查中心

• 批准号: 9201101
• 负责人: Gerardo Heiss
• 金额: $ 142.23万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-11-15 至 2016-11-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9201101
• 关键词: African American; Age; American; American Heart Association; Ancillary Study; Atrial Fibrillation; Behavioral; Biological Markers; Blood Vessels; Cardiology; Cardiovascular Diseases; Cardiovascular system; Caring; Cessation of life; Clinic; Clinical; Cohort Studies; Communities; Contracts; Coronary heart disease; County; Dietary intake; Environmental Risk Factor; Epidemiologic Studies; Etiology; Event; Genetic; Genetic Markers; Health Status; Heart failure; Incidence; Individual; Inpatients; Measurement; Medical; Monitor; Myocardial Infarction; Natural History; Outcome; Outcomes Research; Outpatients; Participant; Probability Samples; Recruitment Activity; Research Personnel; Risk Factors; Staging; Stroke; Telephone; Training; Ventricular Dysfunction; Visit; Washington; Woman; aged; cohort; college; data sharing; demographics; design; follow-up; human old age (65+); member; men; mortality; prospective; pulmonary function; social; trend

ARIC is a prospective epidemiologic study conducted in four U.S. communities: Washington County, MD; Forsyth County, NC; Jackson, MS; and Minneapolis, MN. The study is designed to monitor the trends in incidence and mortality of coronary heart disease (CHD) and heart failure in communities, and to investigate the etiology, natural history, and progression of subclinical and clinical cardiovascular disease such as CHD, heart failure, and stroke. Accordingly, ARIC includes a Community Surveillance Component and Cohort Study Component. For the community surveillance, the four communities are investigated to determine the occurrence of hospitalized myocardial infarction and CHD deaths in approximately 800,000 men and women aged 35-84 years. Starting in 2006, surveillance of inpatient (ages 55 years and older) and outpatient heart failure (ages 65 years and older) is included for the events beginning in 2005. Under the new contract, community surveillance will continue to monitor long-term trends in hospitalized MI, CHD deaths, and heart failure (inpatient and outpatient). For the cohort study, approximately 4,000 individuals aged 45-64 years were recruited by probability sampling from each of the four communities under surveillance. A total of 15,792 participants (11,478 whites, 4,266 African Americans, and 48 other) received an extensive baseline examination in 1987-1989. Three repeat examinations were conducted in 1990-92, 1993-95, and 1996-98. The examinations collected information on demographics, psycho-social and behavioral factors, dietary intakes, physical measurements, and biological and genetic markers. Under the new contract, the surviving cohort members will receive another clinic exam to characterize heart failure stages, identify genetic and environmental factors leading to ventricular dysfunction and vascular stiffness, and assess longitudinal changes in pulmonary function and identify determinants of its decline. Participants are also contacted twice a year by telephone to assess health status. Under the new contract, the study will also be enhanced with cardiovascular outcomes research to assess quality and outcomes of medical care for heart failure risk factors and heart failure.

ARIC是一项在四个美国社区进行的前瞻性流行病学研究：马里兰州华盛顿县、北卡罗来纳州福赛斯县、密苏里州杰克逊和明尼阿波利斯。这项研究旨在监测社区冠心病(CHD)和心力衰竭的发病率和死亡率的趋势，并调查亚临床和临床心血管疾病(如CHD、心力衰竭和中风)的病因、自然病史和进展。因此，ARIC包括社区监测部分和队列研究部分。 在社区监测方面，对这四个社区进行了调查，以确定年龄在35-84岁之间的大约80万男性和女性住院心肌梗死和冠心病死亡的发生情况。从2006年开始，对住院患者(55岁及以上)和门诊心力衰竭(65岁及以上)的监测包括在2005年开始的事件中。根据新的合同，社区监测将继续监测住院心肌梗死、冠心病死亡和心力衰竭(住院和门诊患者)的长期趋势。 在队列研究中，从受监测的四个社区中每个社区以概率抽样的方式招募了大约4,000名年龄在45-之间的人。在1987-1989年，共有15,792名参与者(11,478名白人，4,266名非裔美国人和48名其他人)接受了广泛的基线检查。在1990-92年、1993-95年和1996-98年进行了三次重复检查。这些检查收集了有关人口统计学、心理社会和行为因素、饮食摄入量、体格测量以及生物和遗传标记的信息。根据新的合同，幸存的队列成员将接受另一次临床检查，以确定心力衰竭阶段的特征，识别导致心功能障碍和血管僵硬的遗传和环境因素，评估肺功能的纵向变化，并确定其下降的决定因素。参与者每年还会通过电话联系两次，以评估健康状况。 根据新合同，这项研究还将加强心血管结果研究，以评估心力衰竭风险因素和心力衰竭的医疗护理质量和结果。