IGF::OT::IGF ATHEROSCLEROSIS IN RISK COMMUNITIES - FIELD CENTER - CORE STUDY OPERATIONS

社区动脉粥样硬化风险 (ARIC) 研究于 1985 年启动，包括两个部分：基于社区的监测和前瞻性队列研究。社区监测旨在监测美国四个社区住院心肌梗塞（MI）和致命冠心病（CHD）的趋势：北卡罗来纳州福赛斯县；杰克逊，MS；明尼苏达州明尼阿波利斯郊区；和马里兰州华盛顿县。 2005 年增加了对住院心力衰竭 (HF) 事件的监测。选择社区提供四 (4) 个地理位置的数据，这些地理位置的死亡率范围包括城市、郊区和农村。该队列研究旨在调查来自同一社区的中年白人或非裔美国成年人动脉粥样硬化的危险因素和自然史以及临床动脉粥样硬化的发展。该研究招募了 15,792 名最初年龄在 45-64 岁的白人或非裔美国人参与者，选定的参与者在研究的前十年（1987-1989、1990-1992、1993-1995 和 1996-1998）接受了三年一次的临床检查，并在 2011-2013 年进行了第五次临床检查，提供了关于身体、行为、遗传和心理社会因素。自 1988 年以来，每年都会联系该队列，并于 2011 年开始每半年进行一次随访。截至 2014 年，研究结果已发表在 1,400 多份出版物中。使用颈动脉和腘动脉 B 型超声、踝肱指数测量和视网膜摄影，以及腹主动脉 CT 和止血因素，对参与者进行了亚临床动脉粥样硬化的证据检查；已建立的和假定的实验室风险标记；社会经济、心理、行为和环境特征；和遗传因素。考试包括各种组成部分，最近的考试中添加了由赠款资助的详细认知功能测试部分。

The Atherosclerosis Risk in Communities (ARIC) Study was initiated in 1985 with two components: community-based surveillance and a prospective cohort study. The community surveillance aimed to monitor trends in hospitalized myocardial infarction (MI), fatal coronary heart disease (CHD) in four U.S. communities: Forsyth County, NC; Jackson, MS; suburbs of Minneapolis, MN; and Washington County, MD. Surveillance for hospitalized heart failure (HF) events was added in 2005. The communities were selected to provide data across four (4) geographic locations with a range of mortality rates, in urban, suburban, and rural settings. The cohort study aimed to investigate the risk factors for and natural history of atherosclerosis and development of clinical atherosclerosis in middle-aged white or African American adults from the same communities. The study recruited in 15,792 white or African American participants initially aged 45-64 years and selected participants received triennial clinical exams over the first ten years of the study (1987-1989, 1990-1992, 1993-1995, and 1996-1998), with a fifth clinical exam in 2011-2013, providing a rich set of data on physical, behavioral, genetic, and psychosocial factors. Since 1988, the cohort has been contacted annually and in 2011 semiannual follow-up was initiated. Findings have been presented in over 1,400 publications as of 2014. Participants were examined for evidence of subclinical atherosclerosis using B-mode ultrasound in carotid and popliteal arteries, ankle-brachial index measurement, and retinal photography and, in subsets, abdominal aortic CT, and hemostatic factors; established and putative laboratory risk markers; socioeconomic, psychological, behavioral, and environmental characteristics; and genetic factors. Examinations included a variety of components, with a grant-funded detailed cognitive function testing component added in the most recent exam.