IGF::OT::IGF ATHEROSCLEROSIS IN RISK COMMUNITIES - FIELD CENTER - CORE STUDY OPERATIONS

IGF::OT::IGF 动脉粥样硬化风险社区 - 现场中心 - 核心研究操作

• 批准号: 9915754
• 负责人: Gerardo Heiss
• 金额: $ 76.55万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-11-15 至 2019-11-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9915754
• 关键词: Abdomen; Adult; African American; Ancillary Study; Ankle; Atherosclerosis; Atherosclerosis Risk in Communities; Behavioral; Behavioral Genetics; Carotid Arteries; Characteristics; Clinical; Cohort Studies; Collaborations; Communities; Contracts; Coronary heart disease; County; Data; Data Collection; Data Set; Event; Fostering; Funding; Genetic; Geographic Locations; Goals; Grant; Heart failure; Hemostatic Agents; Laboratories; Measurement; Monitor; Myocardial Infarction; Natural History; Participant; Photography; Policies; Process; Prospective cohort study; Psychosocial Factor; Publications; Research Personnel; Retinal; Risk Factors; Risk Marker; Structure of popliteal artery; Subgroup; Testing; Ultrasonography; United States National Institutes of Health; Washington; aged; base; caucasian American; clinical development; clinical predictors; cognitive function; cohort; data sharing; follow-up; indexing; middle age; mortality; operation; psychologic; recruit; rural setting; socioeconomics; suburb; trend

The Atherosclerosis Risk in Communities (ARIC) Study was initiated in 1985 with two components: community-based surveillance and a prospective cohort study. The community surveillance aimed to monitor trends in hospitalized myocardial infarction (MI), fatal coronary heart disease (CHD) in four U.S. communities: Forsyth County, NC; Jackson, MS; suburbs of Minneapolis, MN; and Washington County, MD. Surveillance for hospitalized heart failure (HF) events was added in 2005. The communities were selected to provide data across four (4) geographic locations with a range of mortality rates, in urban, suburban, and rural settings. The cohort study aimed to investigate the risk factors for and natural history of atherosclerosis and development of clinical atherosclerosis in middle-aged white or African American adults from the same communities. The study recruited in 15,792 white or African American participants initially aged 45-64 years and selected participants received triennial clinical exams over the first ten years of the study (1987-1989, 1990-1992, 1993-1995, and 1996-1998), with a fifth clinical exam in 2011-2013, providing a rich set of data on physical, behavioral, genetic, and psychosocial factors. Since 1988, the cohort has been contacted annually and in 2011 semiannual follow-up was initiated. Findings have been presented in over 1,400 publications as of 2014. Participants were examined for evidence of subclinical atherosclerosis using B-mode ultrasound in carotid and popliteal arteries, ankle-brachial index measurement, and retinal photography and, in subsets, abdominal aortic CT, and hemostatic factors; established and putative laboratory risk markers; socioeconomic, psychological, behavioral, and environmental characteristics; and genetic factors. Examinations included a variety of components, with a grant-funded detailed cognitive function testing component added in the most recent exam.

社区动脉粥样硬化风险（ARIC）研究始于1985年，包括两个部分：社区监测和前瞻性队列研究。社区监测旨在监测美国四个社区住院心肌梗死（MI）、致死性冠心病（CHD）的趋势：北卡罗来纳州福赛斯县；杰克逊女士;明尼阿波利斯郊区，明尼苏达州；2005年增加了住院心力衰竭（HF）事件的监测。这些社区被选中提供四(4)个地理位置的数据，包括城市、郊区和农村的死亡率范围。该队列研究旨在调查来自同一社区的中年白人或非洲裔美国成年人动脉粥样硬化的危险因素、自然病史和临床动脉粥样硬化的发展。该研究招募了15792名年龄在45-64岁之间的白人或非裔美国人参与者，选定的参与者在研究的前十年（1987-1989年、1990-1992年、1993-1995年和1996-1998年）接受了三年一次的临床检查，并在2011-2013年进行了第五次临床检查，提供了一组关于身体、行为、遗传和社会心理因素的丰富数据。自1988年起，每年对该队列进行随访，2011年开始每半年随访一次。截至2014年，已有1400多份出版物发表了研究结果。通过颈动脉和腘动脉b超、踝肱指数测量、视网膜摄影以及亚组腹主动脉CT和止血因子检查参与者的亚临床动脉粥样硬化证据；已建立和假定的实验室风险标记；社会经济、心理、行为和环境特征；还有遗传因素。考试包括多种成分，在最近的考试中增加了一个由拨款资助的详细认知功能测试成分。