IGF::OT::IGF ATHEROSCLEROSIS IN RISK COMMUNITIES - FIELD CENTER - CORE STUDY OPERATIONS

IGF::OT::IGF 动脉粥样硬化风险社区 - 现场中心 - 核心研究操作

• 批准号: 10074453
• 负责人: Gerardo Heiss
• 金额: $ 78.14万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-11-15 至 2020-11-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10074453
• 关键词: Abdomen; Adult; African American; Ancillary Study; Ankle; Atherosclerosis; Atherosclerosis Risk in Communities; Behavioral; Behavioral Genetics; Carotid Arteries; Characteristics; Clinical; Cohort Studies; Collaborations; Communities; Contracts; Coronary heart disease; County; Data; Data Collection; Data Set; Event; Fostering; Funding; Genetic; Geographic Locations; Goals; Grant; Heart failure; Hemostatic Agents; Laboratories; Measurement; Monitor; Myocardial Infarction; Natural History; Participant; Photography; Policies; Process; Prospective cohort study; Psychosocial Factor; Publications; Research Personnel; Retina; Risk Factors; Risk Marker; Structure of popliteal artery; Subgroup; Testing; Ultrasonography; United States National Institutes of Health; Washington; aged; base; caucasian American; clinical development; clinical examination; clinical predictors; cognitive function; cohort; data sharing; follow-up; indexing; middle age; mortality; operation; psychologic; recruit; rural setting; socioeconomics; suburb; trend

The Atherosclerosis Risk in Communities (ARIC) Study was initiated in 1985 with two components: community-based surveillance and a prospective cohort study. The community surveillance aimed to monitor trends in hospitalized myocardial infarction (MI), fatal coronary heart disease (CHD) in four U.S. communities: Forsyth County, NC; Jackson, MS; suburbs of Minneapolis, MN; and Washington County, MD. Surveillance for hospitalized heart failure (HF) events was added in 2005. The communities were selected to provide data across four (4) geographic locations with a range of mortality rates, in urban, suburban, and rural settings. The cohort study aimed to investigate the risk factors for and natural history of atherosclerosis and development of clinical atherosclerosis in middle-aged white or African American adults from the same communities. The study recruited in 15,792 white or African American participants initially aged 45-64 years and selected participants received triennial clinical exams over the first ten years of the study (1987-1989, 1990-1992, 1993-1995, and 1996-1998), with a fifth clinical exam in 2011-2013, providing a rich set of data on physical, behavioral, genetic, and psychosocial factors. Since 1988, the cohort has been contacted annually and in 2011 semiannual follow-up was initiated. Findings have been presented in over 1,400 publications as of 2014. Participants were examined for evidence of subclinical atherosclerosis using B-mode ultrasound in carotid and popliteal arteries, ankle-brachial index measurement, and retinal photography and, in subsets, abdominal aortic CT, and hemostatic factors; established and putative laboratory risk markers; socioeconomic, psychological, behavioral, and environmental characteristics; and genetic factors. Examinations included a variety of components, with a grant-funded detailed cognitive function testing component added in the most recent exam.

社区动脉粥样硬化风险(ARIC)研究始于1985年，由两部分组成：基于社区的监测和前瞻性队列研究。社区监测旨在监测美国四个社区住院心肌梗死(MI)和致命冠心病(CHD)的趋势：北卡罗来纳州福赛斯县、密苏里州杰克逊、明尼阿波利斯郊区和马里兰州华盛顿县。2005年增加了对住院心力衰竭(HF)事件的监测。这些社区被选择来提供四(4)个地理位置的数据，这些地理位置的死亡率范围在城市、郊区和农村环境中。这项队列研究旨在调查同一社区的中年白人或非洲裔美国成年人中动脉粥样硬化的危险因素和自然病史以及临床动脉粥样硬化的发展。这项研究招募了15,792名白人或非裔美国人，最初年龄在45-之间，选定的参与者在研究的前十年(1987-1989年、1990-1992年、1993-1995年和1996年-1998年)接受了三年一次的临床检查，2011年-2013年进行了第五次临床检查，提供了关于身体、行为、遗传和心理社会因素的丰富数据集。自1988年以来，每年都与该队列进行联系，并于2011年启动了半年一次的后续行动。截至2014年，已有1400多份出版物发表了这一研究结果。受试者接受了颈动脉和月国动脉的B型超声、踝臂指数测量和视网膜照相以及腹主动脉CT和止血因素的检查，以寻找亚临床动脉粥样硬化的证据；已建立和假定的实验室风险标记；社会经济、心理、行为和环境特征；以及遗传因素。考试包括各种组成部分，最近一次考试中增加了拨款资助的详细认知功能测试组成部分。