HUMAN REQUIREMENTS FOR THE NUTRIENT CHOLINE

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 胆碱是一种对细胞膜的结构完整性和信号功能至关重要的膳食营养素;它是膳食中甲基的主要来源，并且它直接影响胆碱能神经传递、跨膜信号传导和脂质转运/代谢。 这一建议的主要前提是，人类需要胆碱的饮食来源，这种需求具有显着的个体差异。 研究人员认为，雌激素和常见的遗传多态性调节这种饮食对胆碱的需求。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Choline is a dietary nutrient essential for the structural integrity and signaling functions of cell membranes; it is the major source of methyl-groups in the diet, and it directly affects cholinergic neurotransmission, transmembrance signaling and lipid transport/metabolism. The major premise for this proposal is that humans require a dietary source of choline and that this requirement has significant individual variation. The investigators suggest that estrogen and common genetic polymorphisms modulate this dietary requirement for choline.